1. Selective orexin receptor antagonists.
- Author
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Lebold TP, Bonaventure P, and Shireman BT
- Subjects
- Animals, Drug Discovery, Humans, Hypothalamus drug effects, Hypothalamus metabolism, Intracellular Signaling Peptides and Proteins metabolism, Neuropeptides metabolism, Orexin Receptors metabolism, Orexins, Orexin Receptor Antagonists, Small Molecule Libraries chemistry, Small Molecule Libraries pharmacology
- Abstract
The orexin, or hypocretin, neuropeptides (orexin-A and orexin-B) are produced on neurons in the hypothalamus which project to key areas of the brain that control sleep-wake states, modulation of food intake, panic, anxiety, emotion, reward and addictive behaviors. These neuropeptides exert their effects on a pair of G-protein coupled receptors termed the orexin-1 (OX1) and orexin-2 (OX2) receptors. Emerging biology suggests the involvement of these receptors in psychiatric disorders as they are thought to play a key role in the regulation of multiple systems. This review is intended to highlight key selective OX1 or OX2 small-molecule antagonists., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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