1. Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity.
- Author
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Kiem PV, Huyen LT, Hang DT, Nhiem NX, Tai BH, Anh HL, Cuong PV, Quang TH, Minh CV, Dau NV, Kim YA, Subedi L, Kim SY, and Kim SH
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal chemistry, Anti-Inflammatory Agents, Non-Steroidal isolation & purification, Cell Line, Circular Dichroism, Magnetic Resonance Spectroscopy, Mice, Nitric Oxide antagonists & inhibitors, Nitric Oxide biosynthesis, Quinones chemistry, Quinones isolation & purification, Quinones pharmacology, Sesquiterpenes chemistry, Sesquiterpenes isolation & purification, Stereoisomerism, omega-N-Methylarginine pharmacology, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Porifera chemistry, Sesquiterpenes pharmacology
- Abstract
Using various chromatographic methods, five new sesquiterpene derivatives named smenohaimiens A-E (1-5) and five known, 19-hydroxy-polyfibrospongol B (6), ilimaquinone (7), dictyoceratin C (8), polyfibrospongol A (9), and polyfibrospongol B (10) were isolated from the marine sponge Smenospongia cerebriformis Duchassaing & Michelotti, 1864. Their structures were assigned by 1D, 2D NMR spectroscopic analysis, HR ESI MS, and calculations of the electron circular dichroism spectra. All compounds were evaluated for the inhibitory activity against NO production in lipopolysaccharide-stimulated in BV2 microglia cells. As the results, compound 7 significantly inhibited NO production with the IC
50 value of 10.40±1.28µM. The remaining compounds showed moderate inhibitory NO production activities with IC50 values ranging from 24.37 to 30.43µM., (Copyright © 2017 Elsevier Ltd. All rights reserved.)- Published
- 2017
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