1. The 3D Genome: EZH2 Comes into the Fold.
- Author
-
Brien GL and Bracken AP
- Subjects
- Chromatin genetics, Chromatin metabolism, Enhancer of Zeste Homolog 2 Protein metabolism, Humans, Lymphoma, Non-Hodgkin metabolism, Lymphoma, Non-Hodgkin pathology, Enhancer of Zeste Homolog 2 Protein genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics methods, Lymphoma, Non-Hodgkin genetics, Mutation
- Abstract
EZH2 is an oncogene in non-Hodgkin lymphoma. Understanding the underlying pathogenic mechanisms will be essential to improve treatments for patients with EZH2 mutant lymphomas. Recently Donaldson-Collier and colleagues (Nat. Genet. 2019; published online January 28, https://doi.org/10.1038/s41588-018-0338-y) examined the effects of mutant EZH2 on the 3D architecture of the lymphoma genome, highlighting the potential relevance of chromatin folding dynamics., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
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