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Your search keyword '"Braghiroli, D."' showing total 2 results
Start Over Author "Braghiroli, D." Publisher elsevier science ltd
2 results on '"Braghiroli, D."'

1. A novel class of allosteric modulators of AMPA/Kainate receptors.

Author

Cannazza G, Jozwiak K, Parenti C, Braghiroli D, Carrozzo MM, Puia G, Losi G, Baraldi M, Lindner W, and Wainer IW

Subjects
Administration, Oral, Animals, Benzothiadiazines chemistry, Combinatorial Chemistry Techniques, Hippocampus drug effects, Molecular Structure, Rats, Sulfonamides chemistry, Benzenesulfonamides, Benzothiadiazines pharmacology, Models, Molecular, Receptors, AMPA drug effects, Receptors, Kainic Acid drug effects, Sulfonamides chemical synthesis, Sulfonamides pharmacology
Abstract

The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.

Published
2009
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2. Synthesis and antiplatelet activity of gemfibrozil chiral analogues.

Author

Ammazzalorso A, Amoroso R, Baraldi M, Bettoni G, Braghiroli D, De Filippis B, Duranti A, Moretti M, Tortorella P, Tricca ML, and Vezzalini F

Subjects
Gemfibrozil analogs & derivatives, Humans, In Vitro Techniques, Molecular Structure, Structure-Activity Relationship, Blood Platelets drug effects, Gemfibrozil chemical synthesis, Gemfibrozil pharmacology, Platelet Aggregation Inhibitors chemical synthesis, Platelet Aggregation Inhibitors pharmacology
Abstract

The chiral analogues of gemfibrozil 5-(2,5-dimethylphenoxy)-2-methylpentanoic acid and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid were synthesized in optically active form using (S)-4-(1-methylethyl)-2-oxazolidinone as chiral auxiliary. All compounds inhibit human platelet aggregation. From these data, one can surmise that all tested compounds and gemfibrozil act at the platelet level with different mechanism than that of ASA, even if with a different potency.

Published
2002
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