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Start Over Author "Bingham AH" Publisher elsevier science ltd
2 results on '"Bingham AH"'

1. Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors.

Author

Bingham AH, Davenport RJ, Fosbeary R, Gowers L, Knight RL, Lowe C, Owen DA, Parry DM, and Pitt WR

Subjects
Cell Line, Tumor, Drug Evaluation, Preclinical, E-Selectin metabolism, Enzyme Inhibitors chemistry, Humans, Models, Molecular, Molecular Structure, Pyrimidines chemical synthesis, Pyrimidines chemistry, Stereoisomerism, Structure-Activity Relationship, Enzyme Inhibitors chemical synthesis, Enzyme Inhibitors pharmacology, I-kappa B Kinase antagonists & inhibitors, Pyrimidines pharmacology
Abstract

The synthesis and structure-activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported.

Published
2008
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2. A novel series of potent and selective IKK2 inhibitors.

Author

Bingham AH, Davenport RJ, Gowers L, Knight RL, Lowe C, Owen DA, Parry DM, and Pitt WR

Subjects
Enzyme Inhibitors pharmacology, I-kappa B Kinase, Pyrimidines pharmacology, Enzyme Inhibitors chemical synthesis, Protein Serine-Threonine Kinases antagonists & inhibitors, Protein Serine-Threonine Kinases metabolism, Pyrimidines chemical synthesis
Abstract

A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.

Published
2004
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