1. CD31 regulates metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway.
- Author
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Zhang YY, Kong LQ, Zhu XD, Cai H, Wang CH, Shi WK, Cao MQ, Li XL, Li KS, Zhang SZ, Chai ZT, Ao JY, Ye BG, and Sun HC
- Subjects
- Adaptor Proteins, Signal Transducing, Animals, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular metabolism, Cell Line, Tumor, Epithelial-Mesenchymal Transition genetics, Focal Adhesion Kinase 1 metabolism, Hep G2 Cells, Humans, Intracellular Signaling Peptides and Proteins metabolism, Liver Neoplasms genetics, Liver Neoplasms metabolism, Male, Membrane Proteins metabolism, Mice, Inbred BALB C, Mice, Nude, Neoplasm Metastasis, Platelet Endothelial Cell Adhesion Molecule-1 genetics, Protein Synthesis Inhibitors pharmacology, Proto-Oncogene Proteins c-akt metabolism, Signal Transduction drug effects, Signal Transduction genetics, Carcinoma, Hepatocellular drug therapy, Cycloheximide pharmacology, Epithelial-Mesenchymal Transition drug effects, Liver Neoplasms drug therapy, Platelet Endothelial Cell Adhesion Molecule-1 metabolism, Xenograft Model Antitumor Assays methods
- Abstract
Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) is a well-known marker of endothelial cells and a key factor for adhesion and accumulation of platelets. CD31 plays roles in cell proliferation, apoptosis, migration, and cellular immunity. CD31 is also expressed on tumor cells, such as breast cancer cells and non-Hodgkin's lymphomas, and contributes to tumor cell invasion. Here, our experiments show that CD31 promotes metastasis by inducing the epithelial-mesenchymal transition in hepatocellular carcinoma by up-regulating integrin β1 via the FAK/Akt signaling pathway., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2018
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