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Start Over Author "Gouas D" Publisher elsevier science ireland
2 results on '"Gouas D"'

1. Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand.

Author

Ortiz-Cuaran S, Villar S, Gouas D, Ferro G, Plymoth A, Khuhaprema T, Kalalak A, Sangrajrang S, Friesen MD, Groopman JD, and Hainaut P

Subjects
Adult, Aged, Carcinoma, Hepatocellular blood, Carcinoma, Hepatocellular pathology, Case-Control Studies, DNA analysis, DNA genetics, Female, Hepatitis B blood, Hepatitis B virology, Hepatitis B virus genetics, Humans, Liver Cirrhosis blood, Liver Cirrhosis pathology, Liver Neoplasms blood, Liver Neoplasms etiology, Liver Neoplasms pathology, Male, Middle Aged, Poisons adverse effects, Polymerase Chain Reaction, Risk Factors, Viral Regulatory and Accessory Proteins, Aflatoxins adverse effects, Biomarkers blood, Carcinoma, Hepatocellular etiology, Hepatitis B complications, Liver Cirrhosis complications, Mutation genetics, Trans-Activators blood, Tumor Suppressor Protein p53 genetics
Abstract

Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Based on a case-control in Thailand, we have measured R249S and the status of HBX gene in plasma DNA of 176 cases and 133 referents. Detection of HBX complete sequences was associated with R249S in HCC with no documented prior cirrhosis but not in HCC developing in a context of cirrhosis or in non-cancer chronic liver diseases. Thus, R249S may specifically cooperate with HBX in a pathway to HCC that bypasses cirrhosis., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Published
2013
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2. The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy.

Author

Gouas D, Shi H, and Hainaut P

Subjects
Biomarkers, Tumor analysis, Carcinoma, Hepatocellular diagnosis, Carcinoma, Hepatocellular therapy, Early Diagnosis, Humans, Liver Neoplasms diagnosis, Liver Neoplasms therapy, Aflatoxins toxicity, Carcinoma, Hepatocellular genetics, Codon, Genes, p53, Liver Neoplasms genetics, Mutagens toxicity, Mutation
Abstract

Hepatocellular Carcinoma (HCC) in high-incidence areas (sub-Saharan Africa, South-Eastern Asia) often contains a somatic mutation at codon 249 in TP53 (R249S). This mutation is rare in low-incidence areas of Europe and the United States. There is evidence that R249S occurs as the result of mutagenesis by aflatoxin in a context of HBV chronic infection. Here, we summarize the mechanisms of R249S formation and the possible role of p.R249S protein in HCC pathogenesis. Next, we discuss the significance of R249S as a biomarker to study the natural history of HCC and as a target for therapeutic approaches aimed at restoring wild-type p53 activity.

Published
2009
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