1. Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer.
- Author
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Nadkarni NJ, Geest KD, Neff T, Young BD, Bender DP, Ahmed A, Smith BJ, Button A, and Goodheart MJ
- Subjects
- Adenocarcinoma, Clear Cell genetics, Adenocarcinoma, Clear Cell mortality, Adenocarcinoma, Clear Cell pathology, Adenocarcinoma, Mucinous genetics, Adenocarcinoma, Mucinous mortality, Adenocarcinoma, Mucinous pathology, Adult, Aged, Aged, 80 and over, Cystadenocarcinoma, Serous genetics, Cystadenocarcinoma, Serous mortality, Cystadenocarcinoma, Serous pathology, DNA, Neoplasm analysis, DNA, Neoplasm genetics, Endometrial Neoplasms genetics, Endometrial Neoplasms mortality, Endometrial Neoplasms pathology, Female, Humans, Middle Aged, Neoplasm Recurrence, Local genetics, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local pathology, Ovarian Neoplasms genetics, Ovarian Neoplasms mortality, Polymerase Chain Reaction, Prognosis, Retrospective Studies, Survival Rate, Biomarkers, Tumor genetics, Microvessels pathology, Mutation genetics, Ovarian Neoplasms pathology, Tumor Suppressor Protein p53 genetics
- Abstract
We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was elevated in tumors with p53 null mutations compared to p53 missense mutation or no mutation. Disease recurrence was increased with higher MVD in both unadjusted and adjusted analyses. In adjusted analysis, p53 null mutation was associated with increased recurrence and worse overall survival. Worse overall survival and increased recurrence risk were also associated with the combination of CD31 MVD values >25 vessels/HPF and any p53 mutation. P53 mutation status and MVD may have prognostic significance in patients with advanced-stage ovarian cancer. Tumors with p53 null mutations are likely to be more vascular, contributing to decreased survival and increased recurrence probability., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2013
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