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30 results on '"Vacanti JP"'

1. Assessment of tissue-engineered stomach derived from isolated epithelium organoid units.

Author

Maemura T, Ogawa K, Shin M, Mochizuki H, and Vacanti JP

Subjects
Animals, Animals, Newborn, Gastric Mucosa cytology, Muscle, Smooth cytology, Rats, Epithelial Cells cytology, Stomach transplantation, Tissue Engineering methods
Abstract

Objective: Isolated stomach epithelial organoid units developed on biodegradable polymers were transplanted to assess the feasibility of a tissue-engineered stomach., Background: Despite recent advances in reconstruction techniques, total gastrectomy is still accompanied by various complications. An alternative treatment would be a tissue-engineered stomach, which replaces the mechanical and metabolic functions of a normal stomach., Methods: Stomach epithelial organoid units isolated from neonatal rats were seeded onto biodegradable polymers. The constructs implanted into the omenta of adult rats were harvested for examination at designated times. Nine rats underwent a second operation for anastomosis., Results: The constructs resulted in cyst-like formations showing vascularized tissue with neomucosa lining the lumen. The surface morphology as assessed using scanning electron microscopy was similar to that of a native stomach. Immunohistochemical staining for alpha-actin smooth muscle and gastric mucin indicated the presence of a smooth muscle layer and a well-developed gastric epithelium, respectively. The luminal surface of the anastomosed tissue-engineered stomach was well-covered with epithelium., Conclusions: Epithelium-derived stomach organoid units seeded on biodegradable polymers and transplanted into donor rats were shown to vascularize, survive, and regenerate into complex tissue resembling native stomach. Anastomosis between the units and native small intestine may have the potential to stimulate epithelial growth. This research may provide insight into new approaches to alleviate complications following total gastrectomy., (Copyright 2004 Elsevier Inc.)

Published
2004
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2. Tissue-engineered spinal cord.

Author

Vacanti MP, Leonard JL, Dore B, Bonassar LJ, Cao Y, Stachelek SJ, Vacanti JP, O'Connell F, Yu CS, Farwell AP, and Vacanti CA

Subjects
Animals, Female, Rats, Rats, Inbred F344, Spinal Cord cytology, Spinal Cord Injuries physiopathology, Stem Cells cytology, Nerve Regeneration physiology, Spinal Cord physiology, Spinal Cord Injuries therapy, Stem Cell Transplantation
Published
2001
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3. Regenerative signals for tissue-engineered small intestine.

Author

Kim SS, Kaihara S, Benvenuto M, Choi RS, Kim BS, Mooney DJ, Taylor GA, and Vacanti JP

Subjects
Animals, Animals, Newborn, Biomedical Engineering methods, Hepatectomy, Intestinal Mucosa physiology, Intestinal Mucosa surgery, Intestine, Small physiology, Intestine, Small surgery, Male, Portacaval Shunt, Surgical, Rats, Rats, Inbred Lew, Regeneration, Short Bowel Syndrome surgery, Surgical Mesh, Transplantation, Isogeneic methods, Biocompatible Materials, Intestinal Mucosa transplantation, Intestine, Small transplantation, Polyglycolic Acid, Transplantation, Isogeneic physiology
Published
1999
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4. Anastomosis between tissue-engineered intestine and native small bowel.

Author

Kaihara S, Kim SS, Benvenuto M, Choi R, Kim BS, Mooney D, Tanaka K, and Vacanti JP

Subjects
Animals, Biomedical Engineering methods, Biopolymers, Female, Intestinal Mucosa cytology, Intestinal Mucosa physiology, Male, Polyglycolic Acid, Rats, Rats, Inbred Lew, Regeneration, Transplantation, Isogeneic methods, Transplantation, Isogeneic physiology, Anastomosis, Surgical methods, Intestinal Mucosa surgery, Intestinal Mucosa transplantation, Intestine, Small surgery, Intestine, Small transplantation
Published
1999
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5. Long-term results in pediatric ABO-incompatible liver transplantation.

Author

Varela-Fascinetto G, Treacy SJ, Lillehei CW, Jonas MM, Lund DP, Kevy SV, Pérez A, Zurakowski D, and Vacanti JP

Subjects
Age Factors, Child, Child, Preschool, Humans, Liver Transplantation immunology, Liver Transplantation mortality, Retrospective Studies, Survival Analysis, ABO Blood-Group System, Blood Group Incompatibility, Graft Survival, Liver Transplantation physiology
Published
1999
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6. Immunoisolation of xenogeneic islets using a living tissue engineered cartilage barrier.

Author

Pollok JM, Ibarra C, and Vacanti JP

Subjects
Animals, Biocompatible Materials, Capsules, Cattle, Cell Separation methods, Insulin analysis, Islets of Langerhans cytology, Islets of Langerhans Transplantation pathology, Mice, Mice, Nude, Polyglycolic Acid, Rats, Rats, Inbred Lew, Skin, Transplantation, Heterologous pathology, Cartilage, Articular cytology, Islets of Langerhans Transplantation methods, Transplantation, Heterologous methods
Published
1997
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7. Approaching operational tolerance in long-term pediatric liver transplant recipients receiving minimal immunosuppression.

Author

Varela-Fascinetto G, Treacy SJ, and Vacanti JP

Subjects
Azathioprine administration & dosage, Child, Child, Preschool, Cyclosporine administration & dosage, Dose-Response Relationship, Drug, Drug Tolerance, Follow-Up Studies, Humans, Immunosuppressive Agents administration & dosage, Liver Function Tests, Prednisone therapeutic use, Retrospective Studies, Time Factors, Azathioprine therapeutic use, Cyclosporine therapeutic use, Immunosuppression Therapy methods, Immunosuppressive Agents therapeutic use, Liver Transplantation immunology
Published
1997
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8. Preliminary studies of tissue-engineered intestine using isolated epithelial organoid units on tubular synthetic biodegradable scaffolds.

Author

Choi RS and Vacanti JP

Subjects
Animals, Biodegradation, Environmental, Cell Separation methods, Cytoplasmic Granules enzymology, Cytoplasmic Granules ultrastructure, Female, Intestinal Mucosa cytology, Intestinal Mucosa physiology, Male, Mitosis, Muramidase analysis, Rats, Rats, Inbred Lew, Short Bowel Syndrome surgery, Time Factors, Transplantation, Isogeneic pathology, Biocompatible Materials, Intestinal Mucosa transplantation, Organoids transplantation, Transplantation, Isogeneic methods
Published
1997
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9. Children and families can achieve normal psychological adjustment and a good quality of life following pediatric liver transplantation: a long-term study.

Author

Stone RD, Beasley PJ, Treacy SJ, Twente AW, and Vacanti JP

Subjects
Activities of Daily Living, Child, Child, Preschool, Education, Follow-Up Studies, Humans, Infant, Infant, Newborn, Interviews as Topic, Medical Records, Retrospective Studies, Sports, Liver Transplantation physiology, Liver Transplantation psychology, Nuclear Family psychology, Quality of Life, Social Adjustment
Published
1997
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10. Enhanced survival of transgenic hepatocytes expressing hepatocyte growth factor in hepatocyte tissue engineering.

Author

Kim TH, Lee HM, Utsonomiya H, Ma P, Langer R, Schmidt EV, and Vacanti JP

Subjects
Animals, Cells, Cultured, Hepatocyte Growth Factor genetics, Lactic Acid, Liver Transplantation pathology, Membranes, Artificial, Mice, Mice, Inbred Strains, Mice, Transgenic, Polyesters, Polymers, Hepatocyte Growth Factor biosynthesis, Liver cytology, Liver Transplantation physiology
Published
1997
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11. A new method of xenotransplantation using autologous cartilage as an immunoisolation barrier for the transplantation of xenogeneic islets of Langerhans.

Author

Pollok JM, Ibarra C, and Vacanti JP

Subjects
Animals, Biocompatible Materials, Biodegradation, Environmental, Cattle, Cells, Cultured, Glucose pharmacology, Insulin metabolism, Insulin Secretion, Islets of Langerhans cytology, Islets of Langerhans drug effects, Polyglycolic Acid, Rats, Rats, Inbred Lew, Cartilage, Articular, Islets of Langerhans metabolism, Islets of Langerhans Transplantation methods, Transplantation, Heterologous methods
Published
1997
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14. Regenerative signals for heterotopic hepatocyte transplantation.

Author

Sano K, Cusick RA, Lee H, Pollok JM, Kaufmann PM, Uyama S, Mooney D, Langer R, and Vacanti JP

Subjects
Animals, Cell Division drug effects, Cell Separation methods, Epidermal Growth Factor pharmacology, Islets of Langerhans cytology, Islets of Langerhans drug effects, Islets of Langerhans Transplantation physiology, Liver drug effects, Liver Transplantation pathology, Male, Microspheres, Rats, Rats, Inbred Lew, Transplantation, Heterotopic, Transplantation, Isogeneic, Liver cytology, Liver Regeneration, Liver Transplantation physiology
Published
1996

15. Outcome of subcutaneous islet transplantation improved by a polymer device.

Author

Juang JH, Bonner-Weir S, Vacanti JP, and Weir GC

Subjects
Animals, Biocompatible Materials, Blood Glucose metabolism, Connective Tissue, Evaluation Studies as Topic, Islets of Langerhans Transplantation physiology, Kidney, Mice, Peritoneal Cavity, Polyglycolic Acid, Polyvinyl Alcohol, Transplantation, Heterotopic, Islets of Langerhans Transplantation methods
Published
1995

17. Generation of neo-tendon using synthetic polymers seeded with tenocytes.

Author

Cao Y, Vacanti JP, Ma X, Paige KT, Upton J, Chowanski Z, Schloo B, Langer R, and Vacanti CA

Subjects
Animals, Animals, Newborn, Biodegradation, Environmental, Cattle, Culture Techniques methods, Mice, Mice, Nude, Polyglycolic Acid, Transplantation, Heterologous, Biocompatible Materials, Cell Transplantation, Tendons cytology
Published
1994

19. Heterotopic hepatocyte transplantation using three-dimensional polymers: evaluation of the stimulatory effects by portacaval shunt or islet cell cotransplantation.

Author

Kaufmann PM, Sano K, Uyama S, Schloo B, and Vacanti JP

Subjects
Animals, Biopolymers, Blood Glucose metabolism, Cell Separation, Cell Survival, Cell Transplantation physiology, Cells, Cultured, DNA biosynthesis, Graft Survival physiology, Islets of Langerhans cytology, Islets of Langerhans Transplantation physiology, Liver physiology, Male, Polyvinyl Alcohol, Rats, Rats, Inbred Lew, Transplantation, Heterotopic methods, Transplantation, Isogeneic, Cell Transplantation methods, Islets of Langerhans Transplantation methods, Liver cytology, Portacaval Shunt, Surgical
Published
1994

21. Transplantation of hepatocytes using porous, biodegradable sponges.

Author

Mooney DJ, Kaufmann PM, Sano K, McNamara KM, Vacanti JP, and Langer R

Subjects
Animals, Biodegradation, Environmental, Cells, Cultured, Lactates, Polyesters, Polylactic Acid-Polyglycolic Acid Copolymer, Polymers, Portacaval Shunt, Surgical, Rats, Rats, Inbred Lew, Time Factors, Transplantation, Isogeneic, Biocompatible Materials, Cell Transplantation methods, Lactic Acid, Liver cytology, Polyglycolic Acid
Published
1994

22. Orthotopic liver transplantation can protect small bowel free grafts from rejection.

Author

Lee SK, Perez-Atayde A, Vacanti JP, and Lund DP

Subjects
Animals, Animals, Newborn, Graft Rejection immunology, Intestinal Mucosa pathology, Intestinal Mucosa physiology, Intestinal Mucosa transplantation, Intestine, Small pathology, Intestine, Small physiology, Male, Rats, Rats, Inbred Lew, Rats, Inbred WF, Transplantation, Homologous immunology, Transplantation, Homologous pathology, Transplantation, Isogeneic immunology, Transplantation, Isogeneic pathology, Graft Rejection prevention & control, Intestine, Small transplantation, Liver Transplantation immunology
Published
1994

24. Intraportal injection of specific allogeneic cells can prolong neonatal intestinal free graft survival.

Author

Lee SK, Perez-Atayde A, Takeda T, Vacanti JP, and Lund DP

Subjects
Animals, Animals, Newborn, Cyclosporine therapeutic use, Graft Rejection immunology, Injections, Intravenous, Portal Vein, Rats, Rats, Inbred BN, Rats, Inbred Lew, Rats, Inbred WF, Time Factors, Transplantation, Homologous immunology, Graft Rejection prevention & control, Graft Survival immunology, Immunosuppression Therapy methods, Intestine, Small transplantation, Liver Transplantation immunology, Lymphocyte Transfusion
Published
1994

26. Tissue-engineered growth of bone and cartilage.

Author

Vacanti CA, Kim W, Upton J, Vacanti MP, Mooney D, Schloo B, and Vacanti JP

Subjects
Animals, Animals, Newborn, Cattle, Culture Techniques methods, Mice, Mice, Nude, Polymers, Transplantation, Heterologous, Cartilage cytology, Cartilage transplantation, Osteoblasts cytology, Osteoblasts transplantation, Osteocytes cytology, Osteocytes transplantation, Prostheses and Implants
Published
1993

27. Transplantation of genetically altered hepatocytes using cell-polymer constructs.

Author

Fontaine M, Hansen LK, Thompson S, Uyama S, Ingber DE, Langer R, and Vacanti JP

Subjects
Animals, Blotting, Southern, Cells, Cultured, DNA genetics, DNA isolation & purification, Fluorescent Antibody Technique, Growth Hormone analysis, Growth Hormone biosynthesis, Humans, Liver cytology, Liver Transplantation methods, Male, Polyvinyl Alcohol, Prostheses and Implants, Rats, Rats, Inbred Lew, Retroviridae genetics, beta-Galactosidase genetics, Growth Hormone genetics, Liver Transplantation physiology, Transfection methods
Published
1993

28. Liver transplantation in newborn liver failure: treatment for neonatal hemochromatosis.

Author

Lund DP, Lillehei CW, Kevy S, Perez-Atayde A, Maller E, Treacy S, and Vacanti JP

Subjects
Blood Coagulation Factors analysis, Cyclosporine therapeutic use, Exchange Transfusion, Whole Blood, Female, Hemochromatosis blood, Humans, Immunosuppression Therapy methods, Infant, Newborn, Liver Failure etiology, Liver Transplantation physiology, Male, Methylprednisolone therapeutic use, Prednisone therapeutic use, Hemochromatosis complications, Liver Failure surgery, Liver Transplantation methods
Published
1993

29. Transplantation of enterocytes utilizing polymer-cell constructs to produce a neointestine.

Author

Organ GM, Mooney DJ, Hansen LK, Schloo B, and Vacanti JP

Subjects
Animals, Cell Adhesion physiology, Cell Survival physiology, Epithelium pathology, Epithelium transplantation, Intestinal Mucosa pathology, Male, Rats, Rats, Inbred Lew physiology, Graft Survival physiology, Intestinal Mucosa transplantation, Polyglycolic Acid, Prostheses and Implants
Published
1992

30. Liver transplantation in children: the Boston Center experience in the first 30 months.

Author

Vacanti JP, Lillehei CW, Jenkins RL, Donahoe PK, Cosimi AB, Kleinman R, Grand RJ, and Cho SI

Subjects
Actuarial Analysis, Biliary Atresia mortality, Boston, Child, Child, Preschool, Female, Follow-Up Studies, Graft Rejection, Hospitals, Special, Humans, Immunosuppressive Agents therapeutic use, Male, Postoperative Complications mortality, Biliary Atresia therapy, Liver Transplantation
Published
1987

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