1. Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure.
- Author
-
Luglio M, Marques TCS, Pereira MFB, Delgado AF, de Carvalho WB, Tannuri ACA, Sandy NS, Litvinov N, de Paula CSY, Dos Santos AG, Lazari CDS, Gouvea MSG, de Paula AV, Mendoza TRT, Tanigawa RY, Lima FR, Hirayama AB, Dos Santos IGG, Pinho JRR, Sabino EC, Mendes-Correah MC, Alves VAF, and Marques HHS
- Subjects
- Child, Humans, SARS-CoV-2, Polymerase Chain Reaction, COVID-19 complications, Liver Failure, Acute diagnosis, Liver Failure, Acute etiology, Hepatitis
- Abstract
A new outbreak of hepatitis of unknown origin raised awareness in the international community. A few reports have attempted to associate new cases with adenovirus infection and the immunologic effects of previous SARS-CoV-2 infections through a superantigen mechanism. Moreover, according to a case series, viral isolates were identified in 7 of 10 cases of pediatric patients with hepatitis of unknown origin and acute liver failure. Adenovirus was detected by respiratory secretion polymerase chain reaction in 2 patients, with neither presenting with SARS-CoV-2 acute infection. Clinical and laboratory descriptions and cross-referencing epidemiologic and pathophysiological data can help identify possible disease etiologies., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF