1. Predictive effect of GIPR SNP rs10423928 on glucose metabolism liver fat and adiposity in prediabetic and diabetic subjects
- Author
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Caroline Honsek, Mariya Markova, Andreas Pfeiffer, Rita Schüler, Jürgen Machann, Ulrike Dambeck, Renate Luzía Barbosa-Yañez, and Stefan Kabisch
- Subjects
Adult ,Male ,medicine.medical_specialty ,Physiology ,030209 endocrinology & metabolism ,Context (language use) ,Carbohydrate metabolism ,Polymorphism, Single Nucleotide ,Biochemistry ,Receptors, Gastrointestinal Hormone ,Glucose-dependent Insulinotropic Peptide ,Gipr ,Glucose Metabolism ,Insulin Sensitivity ,Prediabetes ,Diabetes ,Prediabetic State ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Endocrinology ,Predictive Value of Tests ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,SNP ,Allele ,Alleles ,Adiposity ,Aged ,Aged, 80 and over ,business.industry ,Middle Aged ,medicine.disease ,Fatty Liver ,Cross-Sectional Studies ,Glucose ,Postprandial ,Diabetes Mellitus, Type 2 ,Female ,Gastric inhibitory polypeptide receptor ,business ,Biomarkers ,030217 neurology & neurosurgery - Abstract
The gastric inhibitory polypeptide receptor (GIPR) regulates postprandial metabolism. In this context GIPR SNP rs10423928 seems toplay an important role in modulating glucose metabolism and insulinsensitivity. However, evidence regarding thisparticular SNP is still vague.In this study, we collected baseline data from four different dietaryintervention studies. We genotyped 424 subjects with prediabetes and 73with diabetes for GIPR SNP rs10423928 and examined its impact on glucosemetabolism, insulin sensitivity and body fat accumulation.We extended previous data by showing that carriers of the A allele withprediabetes displayed increased fasting glucose (p = 0.015). Unexpectedly,A allele carriers showed lower glucose levels 2 h (p = 0.021) after anoral glucose challenge compared to T/T homozygous individuals. A allelecarriers also showed significantly higher insulin sensitivity (p < 0.001)(assessed by Cederholm Index), indicating an enhanced beta-cell response.This study points to a potential protective role for rs10423928 inglucose metabolism and insulin sensitivity in subjects with prediabetes.Further studies are necessary to confirm these results.
- Published
- 2020