1. De novo malignancy after solid organ transplantation in children.
- Author
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Debray D, Baudouin V, Lacaille F, Charbit M, Rivet C, Harambat J, Iserin F, Di Filippo S, and Guyot C
- Subjects
- Child, Humans, Incidence, Intestine, Small transplantation, Liver Transplantation adverse effects, Lymphoproliferative Disorders epidemiology, Prevalence, Retrospective Studies, Surveys and Questionnaires, Neoplasms epidemiology, Organ Transplantation adverse effects
- Abstract
The aim of this study was to assess the prevalence of de novo malignancy after solid organ transplantation in childhood. A retrospective questionnaire-based survey was sent to 9 referral centers for pediatric organ transplantation in France. Among 1326 children who underwent solid organ transplantation since 1996, 80 (6%) presented with de novo malignancy posttransplantation during childhood: posttransplant lymphoproliferative disease was the most common (5% of pediatric recipients) comprising 80% of all tumors, with a disproportionately high prevalence among combined liver and small bowel recipients (18%). Various solid tumors were observed mainly among kidney recipients. No skin cancer was reported.
- Published
- 2009
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