1. Association of intronic variants of the KCNAB1 gene with lateral temporal epilepsy
- Author
-
Elena Pasini, A. Teresa Giallonardo, Oriano Mecarelli, Roberto Michelucci, Clementina Boniver, Giangennaro Coppola, Francesca Bisulli, Susanna Casellato, Piernanda Vigliano, Umberto Aguglia, Tiziana Granata, Pasquale Striano, Antonia Parmeggiani, Sandro Malacrida, Edoardo Ferlazzo, Carlo Di Bonaventura, Elena Freri, Gabriella Egeo, Giuseppe Gobbi, Giorgia Busolin, Paolo Tinuper, Annio Posar, Maurizio Elia, Amedeo Bianchi, Simona Binelli, Salvatore Striano, Vittoria Cianci, Carlo Nobile, Marco Marchini, G. Busolin, S. Malacrida, F. Bisulli, P. Striano, C. D. Bonaventura, G. Egeo, E. Pasini, V. Cianci, E. Ferlazzo, A. Bianchi, G. Coppola, M. Elia, O. Mecarelli, G. Gobbi, S. Casellato, M. Marchini, S. Binelli, E. Freri, T. Granata, A. Posar, A. Parmeggiani, P. Vigliano, C. Boniver, U. Aguglia, S. Striano, P. Tinuper, A. T. Giallonardo, R. Michelucci, C. Nobile, G., Busolin, S., Malacrida, F., Bisulli, P., Striano, C. D., Bonaventura, G., Egeo, E., Pasini, V., Cianci, E., Ferlazzo, A., Bianchi, G., Coppola, M., Elia, O., Mecarelli, G., Gobbi, S., Casellato, M., Marchini, S., Binelli, E., Freri, T., Granata, A., Posar, A., Parmeggiani, P., Vigliano, C., Boniver, U., Aguglia, Striano, Salvatore, P., Tinuper, A. T., Giallonardo, R., Michelucci, and C., Nobile
- Subjects
Male ,Linkage disequilibrium ,Genotype ,genetics, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study ,Lateral temporal epilepsy ,genetics/metabolism ,genetics/metabolism, um ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,genetics, Kv1.3 Potassium Channel ,methods ,Gene Frequency ,Haplotype analysis ,Humans ,genetics ,Genetic Predisposition to Disease ,genetics, Linkage Disequilibrium, Logistic Models, Male, Polymorphism ,Epilepsy ,Temporal Lobe ,methods, Genotype, Humans, Introns ,Single Nucleotide ,genetics, Proteins ,Allele ,Polymorphism ,Allele frequency ,Genetics ,Kv1.3 Potassium Channel ,KCNAB1 ,Haplotype ,genetics, Logistic Models, Male, Polymorphism ,Intracellular Signaling Peptides and Proteins ,Proteins ,Case-control study ,Odds ratio ,Introns ,Genotype frequency ,lateral temporal epilepsy ,kcnab1 ,snps ,case-control study ,haplotype analysis ,genetics, Protein ,Logistic Models ,Epilepsy, Temporal Lobe ,Neurology ,methods, Genotype, Humans, Intron ,SNPs ,Female ,Neurology (clinical) ,SNP array ,Genome-Wide Association Study - Abstract
The KCNAB1 gene is a candidate susceptibility factor for lateral temporal epilepsy (LTE) because of its functional interaction with LGI1, the gene responsible for the autosomal dominant form of LTE. We investigated association between polymorphic variants across the KCNAB1 gene and LTE. The allele and genotype frequencies of 14 KCNAB1 intronic SNPs were determined in 142 Italian LTE patients and 104 healthy controls and statistically evaluated. Single SNP analysis revealed one SNP (rs992353) located near the 3'end of KCNAB1 slightly associated with LTE after multiple testing correction (odds ratio=2.25; 95\% confidence interval 1.26-4.04; P=0.0058). Haplotype analysis revealed two haplotypes with frequencies higher in cases than in controls, and these differences were statistically significant after permutation tests (Psim=0.047 and 0.034). One of these haplotypes was shown to confer a high risk for the syndrome (odds ratio=12.24; 95\% confidence interval 1.32-113.05) by logistic regression analysis. These results support KCNAB1 as a susceptibility gene for LTE, in agreement with previous studies showing that this gene may alter susceptibility to focal epilepsy.
- Published
- 2011