1. Patients with HFpEF and HFmrEF have different clinical characteristics in Turkey: A multicenter observational study
- Author
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Mustafa Ozan Çakır, Mehmet Tekinalp, Volkan Doğan, Hicaz Zencirkiran Agus, Yunus Çelik, Kadriye Memiç Sancar, Bedri Caner Kaya, Oğuzhan Çelik, Samet Sevinç, Kadir Uğur Mert, Lütfü Bekar, Altuğ Ösken, Özcan Başaran, Cem Çil, Gurbet Özge Mert, Eda Özlek, İbrahim Rencüzoğulları, Serkan Kahraman, Bülent Özlek, Murat Biteker, Kırıkkale Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, Hitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and [Belirlenecek]
- Subjects
Male ,medicine.medical_specialty ,Turkey ,Epidemiology ,Adrenergic beta-Antagonists ,Comorbidity ,Clinic profile ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Sodium Potassium Chloride Symporter Inhibitors ,Risk Factors ,Internal medicine ,Natriuretic Peptide, Brain ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Registries ,Aged ,Heart Failure ,Ejection fraction ,business.industry ,Heart failure with mid-range ejection fraction ,Stroke Volume ,Middle Aged ,medicine.disease ,Peptide Fragments ,Cross-Sectional Studies ,Logistic Models ,Heart failure with preserved ejection fraction ,Echocardiography ,Heart failure ,Cohort ,Multivariate Analysis ,Etiology ,Population study ,Observational study ,Female ,business - Abstract
Background: To determine and compare the demographic characteristics, clinical profile and management of patients with heart failure with mid-range ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF) in a Turkish cohort. Methods: The APOLLON trial (A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejection fractiON) is an observational and multicenter study conducted in Turkey. Consecutive patients admitted to the cardiology clinics who were at least 18 years of age and had HFmrEF or HFpEF were included (NCT03026114). Results: The study population included 1065 (mean age of 67.1 ± 10.6 years, 54% women) patients from 12 sites in Turkey. Among participants, 246 (23.1%) had HFmrEF and 819 (76.9%) had HFpEF. Compared to patients with HFpEF, those with HFmrEF were more likely to be male (57.7 vs 42.2%; p < 0.001), had higher N-terminal pro-B-type natriuretic peptide levels (853 vs 528 pg/ml, p < 0.001), were more likely to have ECG abnormalities (72.4 vs 53.5%, p < 0.001) and hospitalization history for heart failure (28 vs 18.6%; p = 0.002). HFmrEF patients were more likely to use ?-blockers (69.9 vs 55.2%, p < 0.001), aldosterone receptor antagonists (24 vs 14.7%, p = 0.001), statins (37 vs 23%, p < .001), and loop diuretics (39.8 vs 30.5%, p = 0.006) compared to patients with HFpEF. Conclusions: The results of APOLLON study support that the basic characteristics and etiology of HFmrEF are significantly different from HFpEF. This registry also showed that the patients with HFmrEF and HFpEF were younger but undertreated in Turkey compared to patients in western countries. © 2018 European Federation of Internal Medicine 2-s2.0-85056506589 PubMed: 30446354
- Published
- 2019