1. Cognitive psychotherapy treatment decreases peripheral oxidative stress parameters associated with major depression disorder.
- Author
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Kaufmann FN, Gazal M, Mondin TC, Cardoso TA, Quevedo LĂ, Souza LD, Jansen K, Braganhol E, Oses JP, Pinheiro RT, Kaster MP, da Silva RA, and Ghisleni G
- Subjects
- Adult, Depressive Disorder, Major metabolism, Depressive Disorder, Major physiopathology, Depressive Disorder, Major psychology, Female, Humans, Male, Nitric Oxide metabolism, Sulfhydryl Compounds metabolism, Thiobarbituric Acid Reactive Substances metabolism, Cognitive Behavioral Therapy, Depressive Disorder, Major therapy, Oxidative Stress physiology
- Abstract
Introduction: Studies have already pointed out the contribution of oxidative stress in the pathophysiology of major depressive disorder (MDD). The aim of the present study was to investigate the oxidative-antioxidative systems in MDD and in response to cognitive psychotherapies. Oxidative stress were analyzed in 49 MDD patients at baseline, post-treatment, and follow-up; and 49 control subjects without history of psychiatric disorders., Results: MDD subjects presented an increase in oxidative damage related to control subjects for thiobarbituric acid reactive species (TBARS), nitric oxide, and a decrease in total thiol content. Cognitive psychotherapies were able to counteract peripheral oxidative stress in MDD patients, reducing TBARS levels (p<0.001) in the follow-up, nitric oxide (p<0.001) in the post-treatment and follow-up, and increasing the total thiol content (p<0.01) in the post-treatment and follow-up., Conclusion: Oxidative stress was associated with MDD and the regulation of these parameters might represent an important mechanism associated with the clinical improvement of cognitive psychotherapy., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2015
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