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Your search keyword '"de Almeida Medeiros DB"' showing total 2 results
Start Over Author "de Almeida Medeiros DB" Publisher elsevier science
2 results on '"de Almeida Medeiros DB"'

1. Genomic characterization and evolution of Tacaiuma orthobunyavirus (Peribunyaviridae family) isolated in Brazil.

Author

de Melo AB Junior, de Souza WM, Acrani GO, Carvalho VL, Romeiro MF, Tolardo AL, da Silva SP, Cardoso JF, de Oliveira Chiang J, da Silva Gonçalves Vianez JL Júnior, do Socorro da Silva Azevedo R, Figueiredo LTM, da Costa Vasconcelos PF, Nunes MRT, and de Almeida Medeiros DB

Subjects
Animals, Brazil, Bunyaviridae Infections virology, Chlorocebus aethiops, Evolution, Molecular, Genome, Viral genetics, Humans, Phylogeny, RNA, Viral analysis, RNA, Viral genetics, Vero Cells, Orthobunyavirus classification, Orthobunyavirus genetics
Abstract

Tacaiuma virus (TCMV) is antigenically characterized as a member of the Anopheles A complex in the Orthobunyavirus genus, Peribunyaviridae family (Bunyavirales order). Clinically, the TCMV infection is characterized by acute febrile illness with myalgia and arthralgia lasting three to five days. However, the genomic and evolutionary aspect of this virus has not been elucidated. In this study, we described the complete coding sequences of three segments of two TCMV strains isolated in Brazil and three complete coding sequences of the small segment of three TCMV strains. All the strains sequenced in this study showed the typical genomic organization of orthobunyaviruses that infect vertebrates, except for the absence of the open reading frame that encodes the well-described non-structural small protein. This study presents the genomic and evolutionary characterization of TCMV strains and would be helpful for diagnostic purposes and epidemiology., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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2. Molecular characterization of Capim and Enseada orthobunyaviruses.

Author

de Souza WM, Acrani GO, Romeiro MF, Reis O Jr, Tolardo AL, da Silva SP, de Almeida Medeiros DB, Varela M, Nunes MRT, and Figueiredo LTM

Subjects
Animals, Brazil, Genome, Viral, Humans, Nucleocapsid Proteins genetics, Open Reading Frames, Orthobunyavirus genetics, Phylogeny, Viral Nonstructural Proteins genetics, Culicidae virology, Mammals virology, Orthobunyavirus classification, Sequence Analysis, RNA methods
Abstract

Capim and Enseada viruses are members of the genus Orthobunyavirus isolated from mosquitoes and mammals in Brazil. Despite seroprevalence studies indicating human infections in Latin America, these viruses remain relatively unknown and unstudied. In order to better understand the genetic and evolutionary relationships among orthobunyaviruses, we sequenced the three genomic segments of Capim and Enseada orthobunyaviruses. Based on phylogenetic analysis, we demonstrated that these viruses depicted two new distinct clades, one represented by Enseada and another composed of Capim virus. In general, the genome organization and genetic traits of these viruses are similar to other orthobunyaviruses however, the open reading frame (ORF) of the putative nonstructural NSs protein of Enseada orthobunyavirus precedes the nucleocapsid ORF. Overall, our study provides details on the molecular characteristics of the prototype species of two groups within the Orthobunyavirus genus, revealing novel features into the genetic diversity and evolution of this genus., (Copyright © 2016 Elsevier B.V. All rights reserved.)

Published
2016
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