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Start Over Author "Zauli DAG" Publisher elsevier science
2 results on '"Zauli DAG"'

1. Oropouche virus genomic surveillance in Brazil.

Author

Moreira FRR, Dutra JVR, de Carvalho AHB, Reis CR, Rios JSH, Ribeiro MO, Arruda MB, Alvarez P, Souza RP, Voloch C, Zauli DAG, and Aguiar RS

Abstract

Competing Interests: We declare no competing interests. All new Oropouche virus genome sequences were deposited on NCBI GenBank under accessions PQ066768 to PQ066785. We acknowledge all authors who submitted Oropouche virus genome sequences to National Center for Biotechnology Information GenBank, making this and other genomic epidemiology efforts possible. A complete list of data contributors is available in the appendix. Editorial note: The Lancet Group takes a neutral position with respect to territorial claims in published maps and institutional affiliations.

Published
2024
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2. Inflammatory and Pro-resolving Mediators in Frontotemporal Dementia and Alzheimer's Disease.

Author

Fraga VG, Magalhães CA, Loures CMG, de Souza LC, Guimarães HC, Zauli DAG, Carvalho MDG, Ferreira CN, Caramelli P, de Sousa LP, and Gomes KB

Subjects
Aged, Aged, 80 and over, Alzheimer Disease immunology, Annexin A1 blood, Annexin A1 cerebrospinal fluid, Cytokines blood, Cytokines cerebrospinal fluid, Diagnosis, Differential, Female, Frontotemporal Dementia immunology, Genotype, Healthy Volunteers, Humans, Inflammation, Lipoxins blood, Lipoxins cerebrospinal fluid, Male, Middle Aged, Alzheimer Disease metabolism, Annexin A1 metabolism, Cytokines metabolism, Frontotemporal Dementia metabolism, Lipoxins metabolism
Abstract

Chronic inflammation contributes to neuronal death in Alzheimer's disease (AD) and frontotemporal dementia (FTD). Here we evaluated inflammatory and pro-resolving mediators in AD and behavioural variant of FTD (bvFTD) patients compared with controls, since neuroinflamamtion is a common feature in both diseases. Ninety-eight subjects were included in this study, divided into AD (n = 32), bvFTD (n = 30), and control (n = 36) groups. The levels of hsCRP, IL-1β, IL-6, TNF, and TGF-β1, as well as annexin A1 (AnxA1) and lipoxin A4 (LXA4) were measured in blood and cerebrospinal fluid (CSF). The expression profile of AnxA1 was evaluated in peripheral blood mononuclear cells (PBMCs) as well the distribution of ANXA1 rs2611228 polymorphism. We found reduced peripheral levels of hsCRP and TNF in AD compared with bvFTD patients and controls, and increased levels of TGF-β1 in AD compared to controls. Moreover, reduced plasma levels of AnxA1 were observed in bvFTD compared to AD and controls. There was a significant cleavage of AnxA1 in PBMCs in both dementia groups. The results suggest differential regulation of inflammatory and pro-resolving mediators in bvFTD and AD, while AnxA1 cleavage may impair pro-resolving mechanisms in both groups., (Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.)

Published
2019
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