1. Propofol versus isoflurane anesthesia under hypothermic conditions: Effects on intracranial pressure and local cerebral blood flow after diffuse traumatic brain injury in the rat
- Author
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Kasim Ozluk, Ender Korfali, Tulin Alkan, Bulent Goren, Ferda Kahveci, Nevzat Kahveci, Uludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Anestiyoloji Anabilim Dalı., Kahveci, Ferda, Kahveci, Nevzat, Alkan, Tülin, Gören, Bülent, Korfalı, Ender, Özlük, Kasım, AAH-1718-2021, AAH-1792-2021, AAG-7070-2021, and AAG-9356-2021
- Subjects
Rats, wistar ,Laser-doppler flowmetry ,Physiology ,Hemodynamics ,Hypothermia ,Glucose-utilization ,Hematocrit ,Brain injuries ,Disease models, animal ,Blood gas ,Laser flowmeter ,Lcbf ,Ischemia ,Body temperature ,Brain injury ,Propofol ,Intracranial pressure ,Nitrous oxide ,medicine.diagnostic_test ,Isoflurane ,Hippocampal glutamate ,Neuroprotection ,Mean arterial pressure ,Head-injury ,Inhalation anesthetic agent ,Cerebral blood flow ,Head injury ,Anesthesia ,Clinical neurology ,Blood pressure ,Female ,Halothane ,Antioxidant ,Induced hypothermia ,medicine.drug ,Anesthetics, inhalation ,Brain blood flow ,Neurosciences & neurology ,Perfusion pressure ,Hypothermia, induced ,Blood gas analysis ,Sevoflurane ,Brain ischemia ,medicine ,Animals ,Animal model ,Animal experiment ,Cerebral perfusion pressure ,business.industry ,Disease model ,Anesthetics, intravenous ,Moderate hypothermia ,Rectum temperature ,Rats ,Oxygen ,Drug effect ,Metabolism ,Electrical-activity ,Rat ,Surgery ,Brain temperature ,Neurology (clinical) ,Mild hypothermia ,business ,Cerebrovascular circulation - Abstract
BACKGROUND The aim of this study was to compare the cerebral protective effects of two known protective anesthetics, isoflurane and propofol, when these were used in combination with moderate hypothermia (33-34 degreesC) after diffuse traumatic brain injury (TBI) in the rat. We assessed cerebral protection by measuring local cerebral blood flow (LCBF), mean arterial blood pressure (MABP), cerebral perfusion pressure (CPP) and intracranial pressure (ICP). METHODS Sixteen female Wistar rats weighing 275 to 350 g were anesthetized and subjected to an accelerated-impact weight-drop model of diffuse TBI. Hypothermia (33-34 degreesC) was induced 45 minutes after TBI (baseline), and was maintained for 180 minutes. The isoflurane group (n = 8) received 70% N2O in O-2, and isoflurane at 0.9 +/- 0.04%. The propofol group (n = 8) received 70% N2O in O-2 and a propofol infusion (12 mg/kg/hr). LCBF was measured by laser Doppler flowmeter. MABP, ICP, and brain and rectal temperatures were measured every 15 minutes from baseline through 180 minutes. Blood gas and hematocrit testing was also done at baseline and every 60 minutes thereafter to assess the animals' physiological state. RESULTS In the isoflurane group, MABP and CPP decreased significantly from baseline to 180 minutes (p
- Published
- 2001