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1. Comparison of the immunogenicity and reactogenicity of two commercially available hexavalent vaccines administered as a primary vaccination course at 2, 4 and 6 months of age.

Author

Tichmann I, Preidel H, Grunert D, Habash S, Schult R, Maier R, Gildberg PK, Sengespeik HC, Meurice F, and Sänger R

Subjects
Antibodies, Bacterial analysis, Antibodies, Bacterial biosynthesis, Antibodies, Viral analysis, Antibodies, Viral biosynthesis, Female, Germany, Humans, Immunization Schedule, Infant, Male, Single-Blind Method, Vaccines, Combined administration & dosage, Vaccines, Combined adverse effects, Vaccines, Combined immunology
Abstract

Infants (N = 459) were randomly assigned to receive either Infanrix hexa or Hexavac vaccines at 2, 4 and 6 months of age as a primary vaccination schedule. The immunogenicity of the hepatitis B component was statistically significantly higher for Infanrix hexa compared to Hexavac in terms of both seroprotection (98.6% versus 94.7%, p = 0.0302) and GMCs (905.6 versus 226.4, p < 0.0001). Significantly (p < or =0.0001) higher antibody levels against diphtheria and the 3 polio components were also induced by Infanrix hexa. The responses to tetanus, Hib and pertussis components were similar. The incidences of clinically relevant solicited symptoms, unsolicited symptoms or serious adverse events were low in both groups.

Published
2005
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