1. Açaí seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet-fed mice.
- Author
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Santos IB, de Bem GF, da Costa CA, de Carvalho LCRM, de Medeiros AF, Silva DLB, Romão MH, de Andrade Soares R, Ognibene DT, de Moura RS, and Resende AC
- Subjects
- Adipocytes drug effects, Adipose Tissue drug effects, Adipose Tissue metabolism, Adipose Tissue, White drug effects, Angiotensin-Converting Enzyme Inhibitors pharmacology, Animals, Blood Glucose analysis, Blood Pressure drug effects, Body Weight drug effects, Eating drug effects, Enalapril pharmacology, Energy Intake drug effects, Inflammation, Insulin blood, Lipids blood, Male, Mice, Mice, Inbred C57BL, Renin-Angiotensin System drug effects, Seeds, Adipose Tissue, White metabolism, Diet, High-Fat, Euterpe, Oxidative Stress drug effects, Plant Extracts pharmacology, Renin-Angiotensin System physiology
- Abstract
The role of the renin-angiotensin system (RAS), oxidative stress, and inflammation on the development of obesity and its comorbidities has been extensively addressed. Euterpe oleracea Mart. (açaí) seed extract (ASE), with antioxidant and anti-inflammatory properties and capable to modulate plasma renin levels, has been evidenced as a potential regulator of body mass. We hypothesized that the supplementation with ASE might exert beneficial effects on obesity-related white adipose tissue changes and metabolic disorders by interfering with the local adipose tissue overexpression of RAS, inflammation, and oxidative stress in C57BL/6 mice fed a high-fat (HF) diet. The animals were fed a standard diet (10% fat, control), 60% fat (HF), HF + ASE (300 mg/kg per day) and HF + ENA (enalapril, 30 mg/kg per day) for 12 weeks. ASE and ENA prevented weight gain and adiposity, adipocyte hypertrophy, dyslipidemia, and insulin resistance. In adipose tissue, ASE increased the insulin receptor expression and reduced renin and AT1 receptor expression, which was associated with decreased plasma levels of renin and angiotensin II. Differently, ENA increased the expression of angiotensin-conversing enzyme 2, AT2, B2, and Mas receptors in adipose tissue. Also, ASE but not ENA decreased malondialdehyde and 8-isoprostane levels in adipose tissue. Finally, ASE and ENA reduced the adipose tissue inflammatory markers tumor necrosis factor alpha and interleukin 6. These results demonstrate that ASE prevented the adipocyte hypertrophy, obesity, hyperlipidemia, hyperglycemia, and insulin resistance in HF diet-fed mice. The downregulation of RAS in adipose tissue, reducing oxidative stress and inflammation, may contribute to the prevention of obesity-related disorders., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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