1. Detection of novel Human papilloma virus type 82 in laryngeal cancer: case report.
- Author
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Pannone G, Sanguedolce F, Santoro A, Fierro P, Panetti M, Fierro D, Maiello F, De Maria S, Giannattasio A, Serpico R, Lo Muzio L, Metafora S, and Bufo P
- Subjects
- Biopsy, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, DNA Probes, HPV, Genotype, Humans, Laryngeal Neoplasms diagnosis, Laryngeal Neoplasms pathology, Laryngeal Neoplasms surgery, Laryngectomy, Larynx pathology, Larynx virology, Lymphatic Metastasis pathology, Male, Middle Aged, Neck Dissection, Neoplasm Staging, Papillomaviridae genetics, Papillomavirus Infections diagnosis, Papillomavirus Infections pathology, Papillomavirus Infections surgery, Tomography, X-Ray Computed, Carcinoma, Squamous Cell virology, Laryngeal Neoplasms virology, Papillomaviridae classification, Papillomavirus Infections virology
- Abstract
Human papilloma virus infection is thought to play a role in laryngeal carcinogenesis; the variable association reported in literature may be due to wide range of HPV genotypes. We report the case of a 51-year-old man affected by laryngeal squamous cell carcinoma; analysis of DNA extracted by cancer cells by an innovative molecular virology assay (INNO-LiPA HPV Genotyping Extra) showed the presence of two high-risk HPV genotypes, HPV-73 and -82. Immunohistochemical examination confirmed positivity for both capsid protein and viral oncogenic protein E7. Such association has never been reported in literature so far, and a brief discussion on the importance of assessing HPV status in laryngeal cancer is provided., (Copyright 2010 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2010
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