1. The porcine innate immune system: an update.
- Author
-
Mair KH, Sedlak C, Käser T, Pasternak A, Levast B, Gerner W, Saalmüller A, Summerfield A, Gerdts V, Wilson HL, and Meurens F
- Subjects
- Animals, Inflammation immunology, Receptors, Cytoplasmic and Nuclear metabolism, Receptors, Pattern Recognition immunology, Swine immunology, Swine Diseases immunology, Immunity, Innate, Sus scrofa immunology
- Abstract
Over the last few years, we have seen an increasing interest and demand for pigs in biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of their anatomy, genetics, and physiology, and often are the model of choice for the assessment of novel vaccines and therapeutics in a preclinical stage. However, the pig as a model has much more to offer, and can serve as a model for many biomedical applications including aging research, medical imaging, and pharmaceutical studies to name a few. In this review, we will provide an overview of the innate immune system in pigs, describe its anatomical and physiological key features, and discuss the key players involved. In particular, we compare the porcine innate immune system to that of humans, and emphasize on the importance of the pig as model for human disease., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
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