1. Neutropenic enterocolitis: An unusual complication of HCV combination therapy with PEG-IFN and ribavirin.
- Author
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Kasturi KS, Mummadi RR, and Sood GK
- Subjects
- Anti-Bacterial Agents therapeutic use, Antiviral Agents, Drug Therapy, Combination, Enterocolitis, Neutropenic diagnosis, Enterocolitis, Neutropenic drug therapy, Filgrastim, Granulocyte Colony-Stimulating Factor therapeutic use, Hepatitis C drug therapy, Humans, Interferon alpha-2, Male, Middle Aged, Recombinant Proteins, Tomography, X-Ray Computed, Enterocolitis, Neutropenic chemically induced, Interferon-alpha adverse effects, Polyethylene Glycols adverse effects, Ribavirin adverse effects
- Abstract
Drug induced neutropenia as a consequence of intensive chemotherapy for hematological malignancies and solid tumors is known to be associated with severe, life-threatening infections such as neutropenic enterocolitis. However, the neutropenia associated with HCV combination therapy with Pegylated Interferon [PEG-IFN] and ribavirin is considered to be well tolerated in patients without other co-morbidities. We present a case of a severe gastrointestinal complication in a patient receiving HCV combination therapy and advocate caution in continuing therapy in patients with neutropenia, especially in the presence of underlying co-morbidities such as cirrhosis.
- Published
- 2008
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