1. Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation.
- Author
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Li CZ, Jin HH, Sun HX, Zhang ZZ, Zheng JX, Li SH, and Han SH
- Subjects
- Animals, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Antioxidants pharmacology, Antioxidants therapeutic use, Apoptosis drug effects, Cytokines metabolism, Flavanones therapeutic use, Gene Expression Regulation, Enzymologic drug effects, Heme Oxygenase-1 metabolism, Inflammation drug therapy, Kidney metabolism, Kidney pathology, Male, Membrane Proteins metabolism, Mice, Mice, Inbred BALB C, NF-kappa B metabolism, Reactive Oxygen Species metabolism, Cisplatin adverse effects, Cytoprotection drug effects, Flavanones pharmacology, Kidney drug effects, Kidney injuries, Oxidative Stress drug effects
- Abstract
Eriodictyol, a flavonoid present in citrus fruits, has been reported to have antioxidant and anti-inflammatory effects. In this study, the protective effects of eriodictyol on cisplatin (CP)-induced kidney injury were detected. CP-induced kidney injury model was established by administration of CP (20mg/kg). The results showed that treatment of eriodictyol inhibited the production of blood urea nitrogen (BUN), creatinine, MDA, TBARS, reactive oxygen species (ROS), as well as the production of TNF-α, and IL-1β in kidney tissues induced by CP. Eriodictyol also up-regulated the activities of SOD, CAT, and GSH-PX decreased by CP. Furthermore, eriodictyol was found to up-regulate the expression of Nrf2/HO-1 and inhibited CP-induced NF-κB activation in kidney tissues. In conclusion, eriodictyol protected against CP-induced kidney injury through activating Nrf2 and inhibiting NF-κB activation., (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Published
- 2016
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