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Your search keyword '"Deborah Janowitz"' showing total 2 results
Start Over Author "Deborah Janowitz" Publisher elsevier science
2 results on '"Deborah Janowitz"'

1. Alexithymia is associated with increased all-cause mortality risk in men, but not in women: A 10-year follow-up study

Author

Henry Völzke, Jan Terock, Matthias Nauck, Deborah Janowitz, Hans J. Grabe, and Johanna Klinger-König

Subjects
Adult, Male, Alexithymia, media_common.quotation_subject, Sexism, Large population, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Sex differences, Medicine, Humans, Affective Symptoms, 030212 general & internal medicine, ddc:610, Socioeconomic status, media_common, business.industry, 10 year follow up, General population, Sociodemographic factors, Middle Aged, medicine.disease, All-cause mortality, mortality [Affective Symptoms], Psychiatry and Mental health, Clinical Psychology, Feeling, Study of Health in Pomerania, Cohort, Female, business, 030217 neurology & neurosurgery, All cause mortality, Demography, Follow-Up Studies
Abstract

Objective Alexithymia is associated with various mental as well as physical disorders. Some evidence also suggested high alexithymia to increase mortality risk, but these results are few and based on specific sample compositions. We aimed to investigate the impact of alexithymia on mortality risk in a large population based cohort. In addition, we sought to elucidate the effects of the subfactors of alexithymia and sex differences. Methods In a sample of N = 1380 individuals from the Study of Health in Pomerania (SHIP), we investigated the hazard-ratio (HR) of alexithymia as obtained by the Toronto Alexithymia Scale-20 (TAS-20) on all-cause mortality over an average observation time of 10 years. Sex-by-TAS-20-interactions as well as sex-stratified analyses were performed. Results Alexithymia was significantly associated with enhanced mortality risk (HR = 1.033; 95%-CI = 1.008–1.058); p = 0.009). While sex-by-TAS-20 interactions remained insignificant, sex-stratified analyses showed that this effect was only significant in men (HR = 1.050; 95%-CI = 1.022–1.079; p ≤ 0.001), but not in women (HR: 1.008; 95%-CI = 0.960–1.057; p = 0.76). The effect was validated for the “difficulties identifying feelings” (DIF) and “difficulties describing feelings” (DDF) subfactors of the TAS-20. Conclusion Our study supports and extents previous findings by indicating that mortality risk enhancing effects of alexithymia are specific to male subjects and validated for the DIF and DDF facets. Socioeconomic, clinical and metabolic factors were associated with this relationship. Finding that the impact of alexithymia remains stable in the fully adjusted models suggests that yet unidentified additional factors must be considered.

Published
2021

2. Posttraumatic stress disorder is associated with reduced vitamin D levels and functional polymorphisms of the vitamin D binding-protein in a population-based sample

Author

Hans J. Grabe, Henry Völzke, Jan Terock, Sarah Bonk, Anke Hannemann, Deborah Janowitz, Carsten Spitzer, and Sandra Van der Auwera

Subjects
Male, blood [Stress Disorders, Post-Traumatic], Vitamin D-binding protein, genetics [Stress Disorders, Post-Traumatic], blood [Vitamin D-Binding Protein], Pathogenesis, Stress Disorders, Post-Traumatic, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Germany, Prospective Studies, Vitamin D, Vitamin D-Binding Protein, Middle Aged, Pathophysiology, Study of Health in Pomerania, Population Surveillance, genetics [Polymorphism, Single Nucleotide], epidemiology [Vitamin D Deficiency], Female, blood [Vitamin D Deficiency], genetics [Vitamin D-Binding Protein], epidemiology [Stress Disorders, Post-Traumatic], Vitamin, medicine.medical_specialty, epidemiology [Germany], blood [Vitamin D], behavioral disciplines and activities, Polymorphism, Single Nucleotide, vitamin D deficiency, genetics [Vitamin D Deficiency], 03 medical and health sciences, Internal medicine, mental disorders, medicine, Vitamin D and neurology, Humans, ddc:610, Biological Psychiatry, Aged, Pharmacology, business.industry, medicine.disease, Vitamin D Deficiency, 030227 psychiatry, Posttraumatic stress, Endocrinology, Cross-Sectional Studies, chemistry, business, genetics [Vitamin D]
Abstract

Low levels of vitamin D were found to be associated with different mental disorders. However, the role of vitamin D in the pathogenesis of PTSD is unclear. In this study, we aimed at investigating whether PTSD is linked to reduced vitamin D levels and vitamin D deficiency. Moreover, we sought to investigate the role of the vitamin D-binding protein (also group-specific component or Gc) by testing if two functional polymorphisms (rs4588 and rs7041) were associated with vitamin D levels and PTSD.Serum levels of total 25(OH)D were measured in a general-population sample of the Study of Health in Pomerania (SHIP-1). The number of traumatic events and status of PTSD were assessed using the PTSD module of the Structured Clinical Interview for the DSM-IV. Study participants were genotyped for rs4588 and rs7041. Associations of 25(OH)D levels and the genotypes with PTSD were tested in subjects with at least one traumatic event (n = 1653).25(OH)D levels were inversely (OR: 0.96; p = 0.044) and vitamin D deficiency was positively (OR = 2.02; p = 0.028) associated with PTSD. Both polymorphisms of the Gc were associated with 25(OH)D levels and PTSD: Carriers of the CC-genotype of rs4588 showed significantly higher 25(OH)D levels (ß = 0.179, p

Published
2020

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