1. Omega-3 prevents behavior response and brain oxidative damage in the ketamine model of schizophrenia.
- Author
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Zugno AI, Chipindo HL, Volpato AM, Budni J, Steckert AV, de Oliveira MB, Heylmann AS, da Rosa Silveira F, Mastella GA, Maravai SG, Wessler PG, Binatti AR, Panizzutti B, Schuck PF, Quevedo J, and Gama CS
- Subjects
- Animals, Brain drug effects, Brain metabolism, Disease Models, Animal, Dose-Response Relationship, Drug, Glutathione Peroxidase metabolism, Ketamine toxicity, Male, Malondialdehyde metabolism, Mental Disorders etiology, Oxidative Stress drug effects, Protein Carbonylation drug effects, Rats, Rats, Wistar, Schizophrenia chemically induced, Schizophrenia pathology, Sensory Gating drug effects, Superoxide Dismutase metabolism, Thiobarbituric Acid Reactive Substances metabolism, Brain Injuries diet therapy, Brain Injuries etiology, Fatty Acids, Omega-3 administration & dosage, Mental Disorders prevention & control, Schizophrenia complications
- Abstract
Supplementation with omega-3 has been identified as an adjunctive alternative for the treatment of psychiatric disorders, in order to minimize symptoms. Considering the lack of understanding concerning the pathophysiology of schizophrenia, the present study hypothesized that omega 3 prevents the onset of symptoms similar to schizophrenia in young Wistar rats submitted to ketamine treatment. Moreover, the role of oxidative stress in this model was assessed. Omega-3 (0.8g/kg) or vehicle was given by orogastric gavage once daily. Both treatments were performed during 21days, starting at the 30th day of life in young rats. After 14days of treatment with omega-3 or vehicle, a concomitant treatment with saline or ketamine (25mg/kg ip daily) was started and maintained until the last day of the experiment. We evaluated the pre-pulse inhibition of the startle reflex, activity of antioxidant systems and damage to proteins and lipids. Our results demonstrate that supplementation of omega-3 prevented: decreased inhibition of startle reflex, damage to lipids in the hippocampus and striatum and damage to proteins in the prefrontal cortex. Furthermore, these changes are associated with decreased GPx in brain tissues evaluated. Together, our results suggest the prophylactic role of omega-3 against the outcome of symptoms associated with schizophrenia., (Copyright © 2014. Published by Elsevier Ltd.)
- Published
- 2014
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