1. 8-O-Azeloyl-14-benzoylaconine: a new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities.
- Author
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Chodoeva A, Bosc JJ, Guillon J, Decendit A, Petraud M, Absalon C, Vitry C, Jarry C, and Robert J
- Subjects
- Aconitine chemistry, Aconitine isolation & purification, Aconitine toxicity, Alkaloids isolation & purification, Alkaloids toxicity, Cell Line, Tumor, Cell Proliferation drug effects, Humans, Inhibitory Concentration 50, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Structure, Aconitine analogs & derivatives, Aconitum chemistry, Alkaloids chemistry, Alkaloids pharmacology, Plant Roots chemistry
- Abstract
A new alkaloid of Aconitum karacolicum Rapcs, from the Ranunculaceae family, collected in Kirghizstan, was isolated from the roots of this plant, using a purification scheme based upon its in vitro antiproliferative properties against three human tumour cell lines in culture. Structural identification was performed using high resolution MS-MS mass spectrometry and (1)H, (13)C, 2D NOESY NMR spectroscopy analysis. This compound consists of a 14-benzoylaconine moiety substituted on C-8 by an azeloyl chain. It presents in vitro cytotoxicity with an IC(50) of about 10-20 microM, which warrants further investigation on its possible interest in cancer chemotherapy.
- Published
- 2005
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