1. Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases.
- Author
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Carrieri A, Barbarossa A, de Candia M, Samarelli F, Damiano Altomare C, Czarnota-Łydka K, Sudoł-Tałaj S, Latacz G, Handzlik J, Brunetti L, Piemontese L, Limongelli F, Lentini G, and Carocci A
- Subjects
- Humans, Stereoisomerism, Molecular Structure, Neuroprotective Agents chemistry, Neuroprotective Agents pharmacology, Neuroprotective Agents chemical synthesis, Animals, Structure-Activity Relationship, Pyrrolidines chemistry, Pyrrolidines chemical synthesis, Pyrrolidines pharmacology, Alzheimer Disease drug therapy, Neurodegenerative Diseases drug therapy
- Abstract
In pharmaceutical science and drug design the versatility of the pyrrolidine scaffold relating to spatial arrangement, synthetic accessibility and pharmacological profile is a largely explored and most likely interesting one. Nonetheless, few evidences suggest the pivotal role of pyrrolidine as scaffold for multipotent agents in neurodegenerative diseases. We then challenged the enrolling in the field of Alzheimer disease of so far not ravelled targets of this chemical cliché with a structure based and computer-aided design strategy focusing on multi-target action, versatile synthesis as well as pharmacological safeness. To achieve these hits, ten enantiomeric pairs of compounds were obtained and tested, and the biological data will be here presented and discussed. Among the novel compounds, coumarin and sesamol scaffolds containing analogues resulted promising perspectives., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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