1. Total synthesis of the bacillosamine containing alpha-L-serine linked trisaccharide of Neisseria meningitidis
- Author
-
Madhu Emmadi and Suvarn S. Kulkarni
- Subjects
De-Novo Synthesis ,Aminoacid Coupling ,Stereochemistry ,Molecular Conformation ,Stereoselective Glycosylation ,Rare-Sugar ,L serine ,Meningococcal Disease ,Neisseria meningitidis ,medicine.disease_cause ,Biochemistry ,Analytical Chemistry ,Streptococcus-Pneumoniae ,chemistry.chemical_compound ,Serine ,medicine ,Trisaccharide ,Intermolecular Aglycon Transfer ,chemistry.chemical_classification ,Bacillosamine ,Neisseria Meningitides ,Genetic-Characterization ,Organic Chemistry ,Nucleophilic Displacement Of Triflates ,Total synthesis ,Repeating Unit ,Hexosamines ,General Medicine ,D-Fucosamine ,chemistry ,Rare Sugars ,Sugar Building-Blocks ,Glycosylation Conditions ,Trisaccharides - Abstract
Total synthesis of the bacillosamine containing L-serine linked O-trisaccharide of Neisseria meningitidis is described. The synthesis entails installation of two consecutive alpha-linkages including the coupling of bacillosamine with L-serine derivative. (C) 2014 Elsevier Ltd. All rights reserved.
- Published
- 2014