1. Mutations in Neurospora crassa which affect multiple amino acid transport systems.
- Author
-
Wolfinbarger L Jr
- Subjects
- Arginine metabolism, Aspartic Acid metabolism, Cell Division, Chromosome Mapping, Kinetics, Phenylalanine metabolism, Structure-Activity Relationship, Amino Acids metabolism, Biological Transport, Active, Mutation, Neurospora metabolism, Neurospora crassa metabolism
- Abstract
Characterization of a double mutant, his-6: hgu-4, which is unable to utilize L-histidyl-glycine as a source of histidine has revealed a new locus on linkage group V. The hgu-4 genotype results in a generalized reduced transport activity for amino acids, with a concomitant increased resistance to amino acid analogs. Transport rates and analog resistance for amino acids by this mutant are compared to the previously reported transport deficient mutants fpr-1, nap and un-3. Transport of L-aspartate as a function of temperature is examined in a variety of transport deficient strains in an attempt to explain the mode of action of mutation which pleiotropically affect several genetically and biochemically distinct amino acid transport systems.
- Published
- 1976
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