1. Choreographing pluripotency and cell fate with transcription factors.
- Author
-
Gonzales KA and Ng HH
- Subjects
- Animals, Humans, Pluripotent Stem Cells cytology, Transcription Factors genetics, Epigenesis, Genetic physiology, Pluripotent Stem Cells physiology, Signal Transduction physiology, Transcription Factors metabolism
- Abstract
The cellular identity of both pluripotent and differentiated cells is defined by the concerted interplay of transcriptional factors as well as other modulators such as epigenetic and signaling mediators. Therefore, the manipulation of a cell's transcriptional network directly facilitates inter-conversion between cellular identities. Understanding the molecular regulation of cell fate changes, including those involved in pluripotency, is crucial in realizing the practical potential of pluripotent and induced cell types. Here we review the advancements in the role of transcription factors in pluripotency, as well as in the conversion between and within pluripotent and somatic cell types., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2011
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