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Four cases of histologically proven temporal arteritis presenting with atypical clinical, anatomical or evolutive features and raising nosological problems concerning the type of vasculitis involved are presented. In patients with temporal arteritis, some elements are suggestive of periarteritis nodosa. They include peripheral neurological lesions, renal or pleuro-pulmonary lesions and the histological appearance of the temporal artery. Diagnosing periarteritis nodosa in a case of temporal arteritis leads to a special therapeutic strategy.

The drugs and drug combinations responsible for cutaneo-mucosal reactions are very numerous, which explains why this undesireable side effect is the most frequent of all. Multiple pathogenic mechanisms are described: immunoallergic with its different types of reactions, overdosage, idiosyncrasy, drug interactions, etc. The reactions of produced vary from the maculo-papular rash to definitive staining of the skin. A few specific cases have been analyzed: the allergic reactions with penicillins, the photo-toxicity of certain tetracyclines, licheniform eruptions with gold salts or lupus erythematosus with penicillamine. Centralization of pharmacological information is desireable in order to better understand these reactions.