1. [Thiamine (vitamin B1) treatment in patients with alcohol dependence].
- Author
-
Dervaux A and Laqueille X
- Subjects
- Alcoholic Neuropathy drug therapy, Alcoholic Neuropathy etiology, Alcoholism metabolism, Cardiomyopathy, Alcoholic drug therapy, Cardiomyopathy, Alcoholic etiology, Diagnosis, Differential, Drug Administration Routes, Drug Administration Schedule, Humans, Korsakoff Syndrome etiology, Korsakoff Syndrome prevention & control, Malnutrition complications, Symptom Assessment, Thiamine administration & dosage, Thiamine Deficiency etiology, Wernicke Encephalopathy diagnosis, Wernicke Encephalopathy etiology, Wernicke Encephalopathy prevention & control, Alcoholism complications, Thiamine therapeutic use, Thiamine Deficiency drug therapy
- Abstract
Thiamine deficiency (vitamin B1) is common in patients with alcohol dependence. Cognitive impairments may be an early consequence of thiamine deficiency. Wernicke's encephalopathy is underdiagnosed and undertreated. In patients with established Wernicke's encephalopathy, parenteral thiamine 200-500mg three times a day should be given for 3-5 days, followed by oral thiamine 250-1000mg/day. In patients with suspected Wernicke's encephalopathy, parenteral thiamine 250-300mg should be given two times a day for 3-5 days, followed by oral thiamine 250-300mg/day. In patients at high risk of thiamine deficiency, parenteral thiamine 250-500mg/day should be given for 3-5 days, followed by oral thiamine 250-300mg/day. In patients at low risk (with uncomplicated alcohol dependence), oral thiamine 250-500mg/day should be given for 3-5 days, followed by oral thiamine 100-250mg/day., (Copyright © 2016. Published by Elsevier Masson SAS.)
- Published
- 2017
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