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As studies continue into the development of a vaccine for COVID-19, research to understand and address the concerns raised by anti-vaxxers about vaccinations should also be undertaken in tandem. Using the experience of Samoa, which was recently impacted by a measles epidemic, the authors discuss the importance of vaccination to developing countries and the devastation that can be wrought by vaccine-preventable diseases. There are fewer laws on vaccination of adults when compared to those applicable for children, and not all countries have mandatory vaccination laws in place. With increasing anti-vaxxer rhetoric towards the COVID-19 vaccine that is currently in development, the focus has been on reducing the spread of the misinformation through penalties or company interventions, but less so on addressing the underlying concerns of the anti-vaxxer community. The authors suggest that involving anti-vaxxers in the discussion is critical to the acceptance and uptake of the vaccine to COVID-19 when it becomes available.