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Your search keyword '"Toubiana, A."' showing total 34 results
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34 results on '"Toubiana, A."'

2. Effectiveness of one and two doses of acellular pertussis vaccines against laboratory-confirmed pertussis requiring hospitalisation in infants: Results of the PERTINENT sentinel surveillance system in six EU/EEA countries, December 2015 – December 2019

Author

Merdrignac, Lore, Aït El Belghiti, Fatima, Pandolfi, Elisabetta, Acosta, Lesly, Fabiánová, Kateřina, Habington, Adele, García Cenoz, Manuel, Bøås, Håkon, Toubiana, Julie, Tozzi, Alberto E., Jordan, Iolanda, Zavadilová, Jana, O'Sullivan, Niam, Navascués, Ana, Flem, Elmira, Croci, Ilena, Jané, Mireia, Křížová, Pavla, Cotter, Suzanne, Fernandino, Leticia, Bekkevold, Terese, Muñoz-Almagro, Carmen, Bacci, Sabrina, Kramarz, Piotr, Kissling, Esther, and Savulescu, Camelia

Published
2024
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11. Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey

Author

Adam, Marie Noelle, Agha-Mir, Ilhem, Akitani, Sylvia, Amara, Marlène, Arlet, Guillaume, Asensio, Valérie, Autret, Fanny, Baleine, Julien, Barnaud, Guilaine, Barrans, Alain, Barsotti, Katia, Basmaci, Romain, Bednarek, Nathalie, Belgaid, Abdelmalek, Benoist, Grégoire, Bertrou, Anne, Biessy, Hélène, Biran, Valérie, Blanc, Véronique, Blondel, Elodie, Bolot, Pascal, Bosi, Claude, Boyer, Sophie, Brouard, Jacques, Cartier-Riviere, Bernadette, Cascarigny, Françoise, Cattoen, Christian, Chace, Anne, Chalumeau, Martin, Chamouilli, Jean Marc, Chaplain, Chantal, Charachon, Sylvie, Charbonneau, Anne, Cheron, Mireille, Chevallier, Bertrand, Chomienne, Francis, Courouble, Gery, Danekova, Nevena, Dao-Dubremetz, Anne, Daoud, Patrick, Dauger, Stéphane, De Champs, Christophe, De Luca, Danièle, De Briel, André, Decobert, Marion, Desbois, Delphine, Despert, Véronique, Dessein, Rodrigue, Dessioux, Emmanuelle, Dieckmann, Katherine, Dommergues, Marie Aliette, Dorangeon, Elodie, Doucet-Populaire, Florence, Dubos, François, Dubourg, Grégory, Dufour, Marie Josée, Duval, Véronique, Eitenschenck, Laurence, Epaud, Ralph, Evreux, Françoise, Eyer, Didier, Eyssette-Gayraud, Stéphanie, Fabbro, Chrystèle, Faye, Albert, Ferroni, Agnes, Fos, Marie Pierre, Gallet, Serge, Garandeau, Caroline, Garrec, Hélène, Gaschignard, Jean, Gaudelus, Joel, Geniez, Laurent, Girard, Florent, Glastre, Catherine, Glatz, Isabelle, Goudeau, Alain, Gougeon Jollivet, Anne, Goumy, Pierre, Gouraud, François, Goux, Alain, Grando, Anna, Grimprel, Emmanuel, Guilluy, Olivier, Guyon, Gael, Guyot, Caroline, Haas, Hervé, Haegy-Doehring, Isabelle, Halna, Muriel, Hamdad, Farida, Haouisee, Severine, Herve, Christian, Heyman Guenais, Rachel, Hochart, Anne Cécile, Honore Bouakline, Stéphanie, Hubert, Nathalie, Jan, Didier, Javouhey, Etienne, Jeannot, Emmanuel, Jehan, Josette, Juvin, Marie Emmanuelle, Kalach, Nicolas, Khalfi, Ali, Labrune, Philippe, Lafendi, Leila, Lahrach, Hakim, Laisney, Norbert, Landragin, Danielle, Lapeyre, Fabrice, Laugel, Vincent, Launay, Elise, Lavigne, Jean Philippe, Le Bideau, Marc, Ledru, Sylvie, Lehours, Philippe, Lejri, Nejib, Lemenand, Olivier, Lorrot, Mathie, Lureau, Pierre, M'Bamba, Célestin, Macchi, Valérie, Madhi, Fouad, Marcou, Valérie, Marin, Mariane, Martha, Sandrine Anne, Martinot, Alain, Mezgueldi, Ellia, Micaelo, Maité, Milcent, Karen, Minette Brunel, Delphine, Moissenet, Didier, Moquet, Olivier, Morisot, Cyril, Moulene, Eric, Nicola, Nawal, Oulepsir, Abdelaziz, Pantalone, Leatitia, Patoz, Pierre, Pellegrino, Beatrice, Penel-Capelle, Delphine, Pierre, Marie Hélène, Pinquier, Didier, Pitsch, Aurélia, Plassart, Claire, Porcheret, Huong, Prere, Marie Françoise, Raymond, Josette, Rey, Agnes, Richardin, Florence, Roussellier, Patricia, Roux, Anne Laure, Roybet, Danielle, Sadik, Ahmed, Sarlangue, Jean, Saumureau, Simone, Savoy, Isabelle, Schneider, Jean Marc, Sebag, Olivier, Sivadon-Tardy, Valérie, Soustelle, Nicolas, Texier, Anthony, Thouvenin, Maxime, Toubiana, Julie, Tronc, Fréderic, Twizeyimana, Eterne, Vachee, Anne, Vernet-Garnier, Véronqiue, Vervel, Christine, Violette, Jérémie, Wallet, Fréderic, Warin, Laure, Yangui, Mohamed Amine, Ythier, Hubert, Zimmermann, Brigitte, Ouldali, Naim, Levy, Corinne, Varon, Emmanuelle, Bonacorsi, Stéphane, Béchet, Stéphane, Cohen, Robert, and Angoulvant, François

Published
2018
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13. A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma – A final report

Author

Gnekow, Astrid K., Slavc, Irene, Perilongo, Giorgio, Picton, Sue, Walker, David, Stokland, Tore, Sandstrom, Per Erik, Clausen, Niels, Arola, Mikko, Jonsson, Olafur Gisli, Cruz, Ofelia, Navajas, Aurora, Teijeiro, Anna, Grill, Jacques, Kalifa, Chantal, Raquin, Marie-Anne, Verlooy, Joris, Hans, Volkmar, Pietsch, Torsten, Scheurlen, Wolfram, Hainfellner, Johannes, Giangaspero, Felice, Ironside, James, Robson, Keith, Skullerud, Kari, Scheie, David, NN, Ruchoux, Marie-Madeleine, Jouvet, Anne, Figarella-Branger, Dominique, Lellouch-Toubiana, Arielle, Warmuth-Metz, Monika, Prayer, Daniela, Calderone, Milena, Jaspan, Tim, Bakke, Soren Jacob, Vazquez, Eli, Couanet, Dominique, Kortmann, Rolf D., Diekmann, Karin, Scarzello, Giovanni, Taylor, Roger, Lote, Knut, Giralt, Jordi, Carrie, Christian, Habrand, Jean Louis, Soerensen, Niels, Czech, Thomas, Chumas, Paul, Gustavson, Bengt, Zerah, Michel, Wabbels, Bettina, Pinello, Maria Luisa, Fielder, Alistair, Simmons, Ian, Christoffersen, Terje, Calaminus, Gabriele, Brockmann, Knut, Straeter, Ronald, Ebinger, Friedrich, Hernaiz-Driever, Pablo, Lackner, Herwig, Kennedy, Colin, Glaser, Adam, Stromberg, Bo, Indiano, Jose Ma, Rodary, Chantal, Bouffet, Eric, Frappaz, Didier, Faldum, Andreas, Emser, Angela, De Salvo, Gian Luca, Stephens, Suzanne, Machin, David, Le Deley, Marie-Cécile, Egeland, Thore, Freemann, Carolyn, Schrappe, Martin, Sposto, Richard, Walker, David A., Kandels, Daniela, Picton, Susan, Giorgio Perilongo, Sandstrom, Per Eric, Schmidt, René, Kilmartin, Denise, and De Paoli, Angela

Published
2017
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22. A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma – A final report

Author

Astrid K. Gnekow, David A. Walker, Daniela Kandels, Susan Picton, null Giorgio Perilongo, Jacques Grill, Tore Stokland, Per Eric Sandstrom, Monika Warmuth-Metz, Torsten Pietsch, Felice Giangaspero, René Schmidt, Andreas Faldum, Denise Kilmartin, Angela De Paoli, Gian Luca De Salvo, Irene Slavc, Giorgio Perilongo, Sue Picton, David Walker, Per Erik Sandstrom, Niels Clausen, Mikko Arola, Olafur Gisli Jonsson, Ofelia Cruz, Aurora Navajas, Anna Teijeiro, Chantal Kalifa, Marie-Anne Raquin, Joris Verlooy, Volkmar Hans, Wolfram Scheurlen, Johannes Hainfellner, James Ironside, Keith Robson, Kari Skullerud, David Scheie, null NN, Marie-Madeleine Ruchoux, Anne Jouvet, Dominique Figarella-Branger, Arielle Lellouch-Toubiana, Daniela Prayer, Milena Calderone, Tim Jaspan, Soren Jacob Bakke, Eli Vazquez, Dominique Couanet, Rolf D. Kortmann, Karin Diekmann, Giovanni Scarzello, Roger Taylor, Knut Lote, Jordi Giralt, Christian Carrie, Jean Louis Habrand, Niels Soerensen, Thomas Czech, Paul Chumas, Bengt Gustavson, Michel Zerah, Bettina Wabbels, Maria Luisa Pinello, Alistair Fielder, Ian Simmons, Terje Christoffersen, Gabriele Calaminus, Knut Brockmann, Ronald Straeter, Friedrich Ebinger, Pablo Hernaiz-Driever, Herwig Lackner, Colin Kennedy, Adam Glaser, Bo Stromberg, Jose Ma Indiano, Chantal Rodary, Eric Bouffet, Didier Frappaz, Angela Emser, Suzanne Stephens, David Machin, Marie-Cécile Le Deley, Thore Egeland, Carolyn Freemann, Martin Schrappe, and Richard Sposto

Subjects
Cancer Research, Vincristine, Pediatrics, medicine.medical_specialty, Randomised trial, Chemotherapy, Childhood, Low grade glioma, medicine.medical_treatment, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, law, Interquartile range, Internal medicine, Glioma, medicine, ddc:610, Etoposide, Cancer och onkologi, business.industry, Pediatrik, medicine.disease, Clinical Trial, Carboplatin, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer and Oncology, chemotherapy, childhood, low grade glioma, randomised trial, antineoplastic combined chemotherapy protocols, brain neoplasms, carboplatin, child, child, preschool, etoposide, female, glioma, humans, induction chemotherapy, infant, male, survival analysis, vincristine, business, 030217 neurology & neurosurgery, Progressive disease, medicine.drug
Abstract

Background The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration of 12 months of treatment after resection. Methods Within the European comprehensive treatment strategy for childhood LGG, the International Society of Paediatric Oncology–Low Grade Glioma (SIOP LGG) Committee launched a randomised trial involving 118 institutions and 11 countries to investigate the addition of etoposide (100 mg/m2, days 1, 2 & 3) to a four-course induction of vincristine (1.5 mg/m2 × 10 wkly) and carboplatin (550 mg/m2 q 3 weekly) as part of 18-month continuing treatment programme. Patients were recruited after imaging diagnosis, resection or biopsy with progressive disease/symptoms. Some 497 newly diagnosed patients (M/F 231/266; median age 4.26 years (interquartile range (IQR) 2.02–7.06)) were randomised to receive vincristine carboplatin (VC) (n = 249) or VC plus etoposide (VCE) during induction (n = 248), stratified by age and tumour site. Findings No differences between the two arms were found in term of survival and radiological response. Response and non-progression rates at 24 weeks for VC and VCE, were 46% versus 41%, and 93% versus 91% respectively; 5-year Progression-Free Survival (PFS) and Overall Survival (OS) were 46% (StDev 3.5) versus 45% (StDev 3.5) and 89% (StDev 2.1) versus 89% (StDev 2.1) respectively. Age and diencephalic syndrome are adverse clinical risk factors for PFS and OS. 5-year OS for patients in early progression at week 24 were 46% (StDev 13.8) and 49% (StDev 16.5) in the two arms, respectively. Interpretation The addition of etoposide to VC did not improve PFS or OS. High non-progression rates at 24 weeks justify retaining VC as standard first-line therapy. Infants with diencephalic syndrome and early progression need new treatments to be tested. Future trials should use neurological/visual and toxicity outcomes and be designed to discriminate between the impact on disease outcomes of ‘duration of therapy’ and ‘age at stopping therapy’., Highlights • A randomised trial in the commonest brain tumour type in children – low grade glioma. • Tumour response assessment at 6 months identifies those at greatest risk of subsequent progression and death. • Intensifying induction treatment with etoposide does not improve progression-free survival. • International consortium successfully recruits from 11 European countries in a childhood brain tumour. • Carboplatin hypersensitivity is reduced by coadministration of etoposide.

Published
2017

23. Corrigendum to “A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma – A final report” [Eur J of Canc (2017) 206–225]

Author

Gnekow, Astrid K., Slavc, Irene, Perilongo, Giorgio, Picton, Sue, Walker, David, Stokland, Tore, Sandstrom, Per Erik, Clausen, Niels, Arola, Mikko, Jonsson, Olafur Gisli, Cruz, Ofelia, Navajas, Aurora, Teijeiro, Anna, Grill, Jacques, Kalifa, Chantal, Raquin, Marie-Anne, Verlooy, Joris, Hans, Volkmar, Pietsch, Torsten, Scheurlen, Wolfram, Hainfellner, Johannes, Giangaspero, Felice, Ironside, James, Robson, Keith, Skullerud, Kari, Scheie, David, NN, Ruchoux, Marie-Madeleine, Jouvet, Anne, Figarella-Branger, Dominique, Lellouch-Toubiana, Arielle, Warmuth-Metz, Monika, Prayer, Daniela, Calderone, Milena, Jaspan, Tim, Bakke, Soren Jacob, Vazquez, Eli, Couanet, Dominique, Kortmann, Rolf D., Diekmann, Karin, Scarzello, Giovanni, Taylor, Roger, Lote, Knut, Giralt, Jordi, Carrie, Christian, Habrand, Jean Louis, Soerensen, Niels, Czech, Thomas, Chumas, Paul, Gustavson, Bengt, Zerah, Michel, Wabbels, Bettina, Pinello, Maria Luisa, Fielder, Alistair, Simmons, Ian, Christoffersen, Terje, Calaminus, Gabriele, Brockmann, Knut, Straeter, Ronald, Ebinger, Friedrich, Hernaiz-Driever, Pablo, Lackner, Herwig, Kennedy, Colin, Glaser, Adam, Stromberg, Bo, Indiano, Jose Ma, Rodary, Chantal, Bouffet, Eric, Frappaz, Didier, Faldum, Andreas, Emser, Angela, De Salvo, Gian Luca, Stephens, Suzanne, Machin, David, Le Deley, Marie-Cécile, Egeland, Thore, Freemann, Carolyn, Schrappe, Martin, Sposto, Richard, Walker, David A., Kandels, Daniela, Picton, Susan, Giorgio Perilongo, Sandstrom, Per Eric, Schmidt, René, Kilmartin, Denise, and De Paoli, Angela

Published
2018
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