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Your search keyword '"Sivasankar, S."' showing total 27 results
Start Over Author "Sivasankar, S." Publisher elsevier ltd
27 results on '"Sivasankar, S."'

25. Reap the crop wild relatives for breeding future crops

Author

Bohra, A., Kilian, B., Sivasankar, S., Caccamo, M., Mba, C., McCouch, S.R., Varshney, R.K., Bohra, A., Kilian, B., Sivasankar, S., Caccamo, M., Mba, C., McCouch, S.R., and Varshney, R.K.

Abstract

Crop wild relatives (CWRs) have provided breeders with several 'game-changing' traits or genes that have boosted crop resilience and global agricultural production. Advances in breeding and genomics have accelerated the identification of valuable CWRs for use in crop improvement. The enhanced genetic diversity of breeding pools carrying optimum combinations of favorable alleles for targeted crop-growing regions is crucial to sustain genetic gain. In parallel, growing sequence information on wild genomes in combination with precise gene-editing tools provide a fast-track route to transform CWRs into ideal future crops. Data-informed germplasm collection and management strategies together with adequate policy support will be equally important to improve access to CWRs and their sustainable use to meet food and nutrition security targets.

Published
2022

27. Single-molecule studies of classical and desmosomal cadherin adhesion.

Author

Priest AV, Koirala R, and Sivasankar S

Abstract

Classical cadherin and desmosomal cadherin cell-cell adhesion proteins play essential roles in tissue morphogenesis and in maintaining tissue integrity. Deficiencies in cadherin adhesion are hallmarks of diseases like cancers, skin diseases and cardiomyopathies. Structural studies and single molecule biophysical measurements have revealed critical similarities and surprising differences between these key adhesion proteins. This review summarizes our current understanding of the biophysics of classical and desmosomal cadherin adhesion and the molecular basis for their cross-talk. We focus on recent single molecule measurements, highlight key insights into the adhesion of cadherin extracellular regions and their relation to associated diseases, and identify major open questions in this exciting area of research., Competing Interests: Conflict of Interest: The authors declare no conflict of interest.

Published
2019
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