To mitigate the impact of large-scale renewable energy power on the national grid in China, it is imperative to enhance the flexible peaking capability of coal-fired thermal power units. The coordinated control system, central to the load control of coal-fired units, faces challenges such as multivariable coupling, sluggish response, and uncertain coal quality parameters. This paper introduces a neural network predictive controller based on the improved TPA-LSTM model, aimed at addressing these issues. Initially, a data-driven control model is established to break through the limitations of traditional linear predictive control and effectively handle disturbance uncertainties. Then, a multivariable coordinated control strategy based on the neural network controller is designed, achieving effective decoupling of multiple parameters and ensuring high adaptability across all load conditions. Additionally, by integrating an automatic model updating mechanism, the system can recalibrate in real-time when model mismatches occur due to equipment aging, maintenance, or changes in coal quality, thereby enhancing overall control performance. Simulation results demonstrate that this strategy has excellent control effectiveness, meeting the flexible peaking demands of 1000 MW ultra-supercritical units. The calibration feature of the data-driven model significantly improves control performance following model mismatches., Competing Interests: We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled., (© 2024 The Author(s).)