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Your search keyword '"Lalvani, Ajit"' showing total 19 results
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19 results on '"Lalvani, Ajit"'

1. Risk factors and vectors for SARS-CoV-2 household transmission: a prospective, longitudinal cohort study

Author

Cutajar, Jessica, Quinn, Valerie, Hammett, Sarah, McDermott, Eimèar, Luca, Constanta, Timcang, Kristel, Samuel, Jada, Bremang, Samuel, Evetts, Samuel, Wang, Lulu, Nevin, Sean, Davies, Megan, Tejpal, Chitra, Essoussi, Mohammed, Ketkar, Anjeli V, Miserocchi, Giulia, Catchpole, Harriet, Badhan, Anjna, Dustan, Simon, Day Weber, Isaac J, Marchesin, Federica, Whitfield, Michael G, Poh, John, Kondratiuk, Alexandra, Derqui, Nieves, Koycheva, Aleksandra, Zhou, Jie, Pillay, Timesh D, Crone, Michael A, Hakki, Seran, Fenn, Joe, Kundu, Rhia, Varro, Robert, Conibear, Emily, Madon, Kieran J, Barnett, Jack L, Houston, Hamish, Singanayagam, Anika, Narean, Janakan S, Tolosa-Wright, Mica R, Mosscrop, Lucy, Rosadas, Carolina, Watber, Patricia, Anderson, Charlotte, Parker, Eleanor, Freemont, Paul S, Ferguson, Neil M, Zambon, Maria, McClure, Myra O, Tedder, Richard, Barclay, Wendy S, Dunning, Jake, Taylor, Graham P, and Lalvani, Ajit

Published
2023
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3. Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study

Author

Badhan, Anjna, Varro, Robert, Luca, Constanta, Quinn, Valerie, Cutajar, Jessica, Nichols, Niamh, Russell, Jessica, Grey, Holly, Ketkar, Anjeli, Miserocchi, Giulia, Tejpal, Chitra, Catchpole, Harriet, Nixon, Koji, Di Biase, Berenice, Hopewell, Tamara, Narean, Janakan Sam, Samuel, Jada, Timcang, Kristel, McDermott, Eimear, Bremang, Samuel, Hammett, Sarah, Evetts, Samuel, Kondratiuk, Alexandra, Hakki, Seran, Zhou, Jie, Jonnerby, Jakob, Singanayagam, Anika, Barnett, Jack L, Madon, Kieran J, Koycheva, Aleksandra, Kelly, Christine, Houston, Hamish, Nevin, Sean, Fenn, Joe, Kundu, Rhia, Crone, Michael A, Pillay, Timesh D, Ahmad, Shazaad, Derqui-Fernandez, Nieves, Conibear, Emily, Freemont, Paul S, Taylor, Graham P, Ferguson, Neil, Zambon, Maria, Barclay, Wendy S, Dunning, Jake, and Lalvani, Ajit

Published
2022
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4. An online breathing and wellbeing programme (ENO Breathe) for people with persistent symptoms following COVID-19: a parallel-group, single-blind, randomised controlled trial

Author

Philip, Keir E J, Owles, Harriet, McVey, Stephanie, Pagnuco, Tanja, Bruce, Katie, Brunjes, Harry, Banya, Winston, Mollica, Jenny, Lound, Adam, Zumpe, Suzi, Abrahams, Amiad M, Padmanaban, Vijay, Hardy, Thomas H, Lewis, Adam, Lalvani, Ajit, Elkin, Sarah, and Hopkinson, Nicholas S

Published
2022
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6. Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study

Author

Badhan, Anjna, Dustan, Simon, Tejpal, Chitra, Ketkar, Anjeli V, Narean, Janakan Sam, Hammett, Sarah, McDermott, Eimear, Pillay, Timesh, Houston, Hamish, Luca, Constanta, Samuel, Jada, Bremang, Samuel, Evetts, Samuel, Poh, John, Anderson, Charlotte, Jackson, David, Miah, Shahjahan, Ellis, Joanna, Lackenby, Angie, Singanayagam, Anika, Hakki, Seran, Dunning, Jake, Madon, Kieran J, Crone, Michael A, Koycheva, Aleksandra, Derqui-Fernandez, Nieves, Barnett, Jack L, Whitfield, Michael G, Varro, Robert, Charlett, Andre, Kundu, Rhia, Fenn, Joe, Cutajar, Jessica, Quinn, Valerie, Conibear, Emily, Barclay, Wendy, Freemont, Paul S, Taylor, Graham P, Ahmad, Shazaad, Zambon, Maria, Ferguson, Neil M, and Lalvani, Ajit

Published
2022
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9. Clinical utility of existing and second-generation interferon-γ release assays for diagnostic evaluation of tuberculosis: an observational cohort study

Author

Abdoyeku, David, Davidson, Robert, Dedicoat, Martin, Kunst, Heinke, Loebingher, Michael R, Lynn, William, Nathani, Nazim, O'Connell, Rebecca, Pozniak, Anton, Menzies, Sarah, Whitworth, Hilary S, Badhan, Amarjit, Boakye, Aime A, Takwoingi, Yemisi, Rees-Roberts, Melanie, Partlett, Christopher, Lambie, Heather, Innes, John, Cooke, Graham, Lipman, Marc, Conlon, Christopher, Macallan, Derek, Chua, Felix, Post, Frank A, Wiselka, Martin, Woltmann, Gerrit, Deeks, Jonathan J, Kon, Onn Min, and Lalvani, Ajit

Published
2019
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10. Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study

Author

Adeboyeku, D, Bari, N, Barker, J, Booth, H, Chua, F, Creer, D, Darmalingam, M, Davidson, R N, Dedicoat, M, Dunleavy, A, Figueroa, J, Haseldean, M, Johnson, N, Losewicz, S, Lord, J, Moore-Gillon, J, Packe, G, Pareek, M, Tiberi, S, Pozniak, A, Sanderson, F, Abubakar, Ibrahim, Drobniewski, Francis, Southern, Jo, Sitch, Alice J, Jackson, Charlotte, Lipman, Marc, Deeks, Jonathan J, Griffiths, Chris, Bothamley, Graham, Lynn, William, Burgess, Helen, Mann, Bobby, Imran, Ambreen, Sridhar, Saranya, Tsou, Chuen-Yan, Nikolayevskyy, Vladyslav, Rees-Roberts, Melanie, Whitworth, Hilary, Kon, Onn Min, Haldar, Pranab, Kunst, Heinke, Anderson, Sarah, Hayward, Andrew, Watson, John M, Milburn, Heather, and Lalvani, Ajit

Published
2018
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18. Risk factors and vectors for SARS-CoV-2 household transmission: a prospective, longitudinal cohort study.

Author

Derqui N, Koycheva A, Zhou J, Pillay TD, Crone MA, Hakki S, Fenn J, Kundu R, Varro R, Conibear E, Madon KJ, Barnett JL, Houston H, Singanayagam A, Narean JS, Tolosa-Wright MR, Mosscrop L, Rosadas C, Watber P, Anderson C, Parker E, Freemont PS, Ferguson NM, Zambon M, McClure MO, Tedder R, Barclay WS, Dunning J, Taylor GP, and Lalvani A

Subjects
Humans, Prospective Studies, RNA, Viral genetics, Longitudinal Studies, Risk Factors, Cohort Studies, SARS-CoV-2 genetics, COVID-19 diagnosis, COVID-19 epidemiology
Abstract

Background: Despite circumstantial evidence for aerosol and fomite spread of SARS-CoV-2, empirical data linking either pathway with transmission are scarce. Here we aimed to assess whether the presence of SARS-CoV-2 on frequently-touched surfaces and residents' hands was a predictor of SARS-CoV-2 household transmission., Methods: In this longitudinal cohort study, during the pre-alpha (September to December, 2020) and alpha (B.1.1.7; December, 2020, to April, 2021) SARS-CoV-2 variant waves, we prospectively recruited contacts from households exposed to newly diagnosed COVID-19 primary cases, in London, UK. To maximally capture transmission events, contacts were recruited regardless of symptom status and serially tested for SARS-CoV-2 infection by RT-PCR on upper respiratory tract (URT) samples and, in a subcohort, by serial serology. Contacts' hands, primary cases' hands, and frequently-touched surface-samples from communal areas were tested for SARS-CoV-2 RNA. SARS-CoV-2 URT isolates from 25 primary case-contact pairs underwent whole-genome sequencing (WGS)., Findings: From Aug 1, 2020, until March 31, 2021, 620 contacts of PCR-confirmed SARS-CoV-2-infected primary cases were recruited. 414 household contacts (from 279 households) with available serial URT PCR results were analysed in the full household contacts' cohort, and of those, 134 contacts with available longitudinal serology data and not vaccinated pre-enrolment were analysed in the serology subcohort. Household infection rate was 28·4% (95% CI 20·8-37·5) for pre-alpha-exposed contacts and 51·8% (42·5-61·0) for alpha-exposed contacts (p=0·0047). Primary cases' URT RNA viral load did not correlate with transmission, but was associated with detection of SARS-CoV-2 RNA on their hands (p=0·031). SARS-CoV-2 detected on primary cases' hands, in turn, predicted contacts' risk of infection (adjusted relative risk [aRR]=1·70 [95% CI 1·24-2·31]), as did SARS-CoV-2 RNA presence on household surfaces (aRR=1·66 [1·09-2·55]) and contacts' hands (aRR=2·06 [1·57-2·69]). In six contacts with an initial negative URT PCR result, hand-swab (n=3) and household surface-swab (n=3) PCR positivity preceded URT PCR positivity. WGS corroborated household transmission., Interpretation: Presence of SARS-CoV-2 RNA on primary cases' and contacts' hands and on frequently-touched household surfaces associates with transmission, identifying these as potential vectors for spread in households., Funding: National Institute for Health Research Health Protection Research Unit in Respiratory Infections, Medical Research Council., Competing Interests: Declaration of interests NMF reports grants from the UK Medical Research Council, UK National Institute of Health and Care Research, UK Research and Innovation, Community Jameel, Janssen Pharmaceuticals, Bill & Melinda Gates Foundation, and Gavi, the Vaccine Alliance; consulting fees from the World Bank; payment or honoraria from the Wellcome Trust; travel expenses from WHO; advisory board participation for Takeda; and is a senior editor of the eLife journal. All other authors declare no competing interests., (Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)

Published
2023
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19. Probing the in-vivo reservoir of latent tuberculosis infection.

Author

Lalvani A, Fenn J, and Pillay TD

Subjects
Humans, HIV Infections, Latent Tuberculosis diagnosis, Mycobacterium tuberculosis
Abstract

Competing Interests: AL reports issued patents underpinning IGRA and next-generation IGRA some of which were assigned by the University of Oxford to Oxford Immunotec resulting in royalty entitlements for the University of Oxford and AL. All other authors declare no competing interests.

Published
2021
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