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Competing Interests: LSC reports funding from UK Research and Innovation (UKRI; Biotechnology and Biological Sciences Research Council [BBSRC] and the Medical Research Council [MRC]), for the UK Ageing Network (UKANet) and the Building Links in Ageing Science and Translation (BLAST) ageing network, of which she is co-director; Public Health England; UK SPINE (Research England); Diabetes UK and BIRAX; University of Oxford Medical Sciences Division and Wellcome Trust Health Bridge Fund; the John Fell Fund; Elysium Health; and the Mellon Longevity Science Programme. LSC serves on the strategy advisory board and science, genomics, and technology board of the All Party Parliamentary Group for Longevity; is co-chair of the European Geriatric Medicine Society Ageing Biology Special Interest Group; and deputy chair of the Clinical and Translational Theme panel, Biochemical Society. RGAF reports funding from UKRI (BBSRC and MRC) for UKANet and the BLAST ageing network, of which he is co-director. RGAF serves on the board of the American Federation for Aging Research and the Biogerontology Research Foundation. RGAF reports consultancy fees from BYOMass, the Longevity Vision Fund, and Juvenescence.