Search

Your search keyword '"Brugnara, S."' showing total 13 results
Start Over Author "Brugnara, S." Publisher elsevier ltd
13 results on '"Brugnara, S."'

1. REGOMA-OSS: a large, Italian, multicenter, prospective, observational study evaluating the efficacy and safety of regorafenib in patients with recurrent glioblastoma

Author

Caccese, M., Desideri, I., Villani, V., Simonelli, M., Buglione, M., Chiesa, S., Franceschi, E., Gaviani, P., Stasi, I., Caserta, C., Brugnara, S., Lolli, I., Bennicelli, E., Bini, P., Cuccu, A.S., Scoccianti, S., Padovan, M., Gori, S., Bonetti, A., Giordano, P., Pellerino, A., Gregucci, F., Riva, N., Cinieri, S., Internò, V., Santoni, M., Pernice, G., Dealis, C., Stievano, L., Paiar, F., Magni, G., De Salvo, G.L., Zagonel, V., and Lombardi, G.

Published
2024
Full Text
View/download PDF

2. Immune checkpoint inhibitor associated vitiligo and its impact on survival in patients with metastatic melanoma: an Italian Melanoma Intergroup study

Author

Guida, M., Strippoli, S., Maule, M., Quaglino, P., Ramondetta, A., Chiaron Sileni, V., Antonini Cappellini, G., Queirolo, P., Ridolfi, L., Del Vecchio, M., Cocorocchio, E., Di Giacomo, A.M., Festino, L., Merelli, B., Occelli, M., Brugnara, S., Minisini, A., Sava, S., Tommasi, S., and De Summa, S.

Published
2021
Full Text
View/download PDF

13. MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.

Author

Pellegrini C, Botta F, Massi D, Martorelli C, Facchetti F, Gandini S, Maisonneuve P, Avril MF, Demenais F, Bressac-de Paillerets B, Hoiom V, Cust AE, Anton-Culver H, Gruber SB, Gallagher RP, Marrett L, Zanetti R, Dwyer T, Thomas NE, Begg CB, Berwick M, Puig S, Potrony M, Nagore E, Ghiorzo P, Menin C, Manganoni AM, Rodolfo M, Brugnara S, Passoni E, Sekulovic LK, Baldini F, Guida G, Stratigos A, Ozdemir F, Ayala F, Fernandez-de-Misa R, Quaglino P, Ribas G, Romanini A, Migliano E, Stanganelli I, Kanetsky PA, Pizzichetta MA, García-Borrón JC, Nan H, Landi MT, Little J, Newton-Bishop J, Sera F, Fargnoli MC, and Raimondi S

Subjects
Adolescent, Adult, Aged, Case-Control Studies, Child, Female, Genetic Predisposition to Disease, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Polymorphism, Genetic, Retrospective Studies, Biomarkers, Tumor genetics, Germ-Line Mutation, Melanoma genetics, Receptor, Melanocortin, Type 1 genetics, Skin Neoplasms genetics
Abstract

Background: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls., Methods: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger., Findings: We analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1·54, 95% CI 1·02-2·33), including when analysis was restricted to patients aged 18 years or younger (1·80, 1·06-3·07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1·60, 95% CI 1·05-2·44; p=0·04) and Asp294His (2·15, 1·05-4·40; p=0·04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants., Interpretation: Our pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies., Funding: SPD-Pilot/Project-Award-2015; AIRC-MFAG-11831., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results