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36 results on '"Broto J"'

1. Efficacy of immune checkpoint inhibitors in alveolar soft-part sarcoma: results from a retrospective worldwide registry

Author

Hindi, N., Razak, A., Rosenbaum, E., Jonczak, E., Hamacher, R., Rutkowski, P., Bhadri, V.A., Skryd, A., Brahmi, M., Alshibany, A., Jagodzinska-Mucha, P., Bauer, S., Connolly, E., Gelderblom, H., Boye, K., Henon, C., Bae, S., Bogefors, K., Vincenzi, B., Martinez-Trufero, J., Lopez-Martin, J.A., Redondo, A., Valverde, C., Blay, J.-Y., Moura, D.S., Gutierrez, A., Tap, W., and Martin-Broto, J.

Published
2023
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3. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts

Author

Stacchiotti, S., Miah, A.B., Frezza, A.M., Messiou, C., Morosi, C., Caraceni, A., Antonescu, C.R., Bajpai, J., Baldini, E., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Callegaro, D., De Alava, E., Deoras-Sutliff, M., Dufresne, A., Eriksson, M., Errani, C., Fedenko, A., Ferraresi, V., Ferrari, A., Fletcher, C.D.M., Garcia del Muro, X., Gelderblom, H., Gladdy, R.A., Gouin, F., Grignani, G., Gutkovich, J., Haas, R., Hindi, N., Hohenberger, P., Huang, P., Joensuu, H., Jones, R.L., Jungels, C., Kasper, B., Kawai, A., Le Cesne, A., Le Grange, F., Leithner, A., Leonard, H., Lopez Pousa, A., Martin Broto, J., Merimsky, O., Merriam, P., Miceli, R., Mir, O., Molinari, M., Montemurro, M., Oldani, G., Palmerini, E., Pantaleo, M.A., Patel, S., Piperno-Neumann, S., Raut, C.P., Ravi, V., Razak, A.R.A., Reichardt, P., Rubin, B.P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sapisochin, G., Sbaraglia, M., Scheipl, S., Schöffski, P., Strauss, D., Strauss, S.J., Sundby Hall, K., Tap, W.D., Trama, A., Tweddle, A., van der Graaf, W.T.A., Van De Sande, M.A.J., Van Houdt, W., van Oortmerssen, G., Wagner, A.J., Wartenberg, M., Wood, J., Zaffaroni, N., Zimmermann, C., Casali, P.G., Dei Tos, A.P., and Gronchi, A.

Published
2021
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4. Final analysis of the randomized trial on imatinib as an adjuvant in localized gastrointestinal stromal tumors (GIST) from the EORTC Soft Tissue and Bone Sarcoma Group (STBSG), the Australasian Gastro-Intestinal Trials Group (AGITG), UNICANCER, French Sarcoma Group (FSG), Italian Sarcoma Group (ISG), and Spanish Group for Research on Sarcomas (GEIS)☆

Author

Casali, P.G., Le Cesne, A., Velasco, A.P., Kotasek, D., Rutkowski, P., Hohenberger, P., Fumagalli, E., Judson, I.R., Italiano, A., Gelderblom, H., Penel, N., Hartmann, J.T., Duffaud, F., Goldstein, D., Martin-Broto, J., Gronchi, A., Wardelmann, E., Marréaud, S., Zalcberg, J.R., Litière, S., and Blay, J.-Y.

Published
2021
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5. Gastrointestinal stromal tumours: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Blay, J.Y., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dufresne, A., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S.J., Hall, K Sundby, Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Gronchi, A., and Stacchiotti, S.

Published
2021
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6. An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG)

Author

Bauer, S., Blay, J.Y., van Coevorden, F., Dileo, P., Dürr, H.R., Fiore, M., Grünwald, V., Jones, R., Judson, I., Kettelhack, C., Kopeckova, K., Lazar, A., Lindner, L.H., Martin-Broto, J., Rutkowski, P., Stacchiotti, S., Stoeckle, E., Valverde, C., Verhoef, K., Wardelmann, E., Wartenberg, M., Kasper, B., Baumgarten, C., Garcia, J., Bonvalot, S., Haas, R., Haller, F., Hohenberger, P., Penel, N., Messiou, C., van der Graaf, W.T., and Gronchi, A.

Published
2017
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7. Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group

Author

Stacchiotti, S., Gronchi, A., Fossati, P., Akiyama, T., Alapetite, C., Baumann, M., Blay, J.Y., Bolle, S., Boriani, S., Bruzzi, P., Capanna, R., Caraceni, A., Casadei, R., Colia, V., Debus, J., Delaney, T., Desai, A., Dileo, P., Dijkstra, S., Doglietto, F., Flanagan, A., Froelich, S., Gardner, P.A., Gelderblom, H., Gokaslan, Z.L., Haas, R., Heery, C., Hindi, N., Hohenberger, P., Hornicek, F., Imai, R., Jeys, L., Jones, R.L., Kasper, B., Kawai, A., Krengli, M., Leithner, A., Logowska, I., Martin Broto, J., Mazzatenta, D., Morosi, C., Nicolai, P., Norum, O.J., Patel, S., Penel, N., Picci, P., Pilotti, S., Radaelli, S., Ricchini, F., Rutkowski, P., Scheipl, S., Sen, C., Tamborini, E., Thornton, K.A., Timmermann, B., Torri, V., Tunn, P.U., Uhl, M., Yamada, Y., Weber, D.C., Vanel, D., Varga, P.P., Vleggeert-Lankamp, C.L.A., Casali, P.G., and Sommer, J.

Published
2017
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8. Chemotherapy in patients with localized angiosarcoma of any site: A retrospective european study

Author

Conforti, F, Gronchi, A, Penel, N, Jones, R, Broto, J, Sala, I, Bagnardi, V, Napolitano, A, Pala, L, Pennacchioli, E, Catania, C, Queirolo, P, Grigani, G, Merlini, A, Stacchiotti, S, Comandone, A, Vincenzi, B, Quagliuolo, V, Bertuzzi, A, Boglione, A, Palassini, E, Baldi, G, Blay, J, Ryckewaert, T, Toulmonde, M, Italiano, A, Le Cesne, A, Ray-Coquard, I, Cruz, J, Hernandez-Leon, C, Trufero, J, da Silva Moura, D, Muniz, N, De Pas, T, Conforti F., Gronchi A., Penel N., Jones R. L., Broto J. M., Sala I., Bagnardi V., Napolitano A., Pala L., Pennacchioli E., Catania C., Queirolo P., Grigani G., Merlini A., Stacchiotti S., Comandone A., Vincenzi B., Quagliuolo V., Bertuzzi A., Boglione A., Palassini E., Baldi G. G., Blay J. -Y., Ryckewaert T., Toulmonde M., Italiano A., Le Cesne A., Ray-Coquard I., Cruz J., Hernandez-Leon C. N., Trufero J. M., da Silva Moura D., Muniz N. H., De Pas T., Conforti, F, Gronchi, A, Penel, N, Jones, R, Broto, J, Sala, I, Bagnardi, V, Napolitano, A, Pala, L, Pennacchioli, E, Catania, C, Queirolo, P, Grigani, G, Merlini, A, Stacchiotti, S, Comandone, A, Vincenzi, B, Quagliuolo, V, Bertuzzi, A, Boglione, A, Palassini, E, Baldi, G, Blay, J, Ryckewaert, T, Toulmonde, M, Italiano, A, Le Cesne, A, Ray-Coquard, I, Cruz, J, Hernandez-Leon, C, Trufero, J, da Silva Moura, D, Muniz, N, De Pas, T, Conforti F., Gronchi A., Penel N., Jones R. L., Broto J. M., Sala I., Bagnardi V., Napolitano A., Pala L., Pennacchioli E., Catania C., Queirolo P., Grigani G., Merlini A., Stacchiotti S., Comandone A., Vincenzi B., Quagliuolo V., Bertuzzi A., Boglione A., Palassini E., Baldi G. G., Blay J. -Y., Ryckewaert T., Toulmonde M., Italiano A., Le Cesne A., Ray-Coquard I., Cruz J., Hernandez-Leon C. N., Trufero J. M., da Silva Moura D., Muniz N. H., and De Pas T.

Abstract

Background: We retrospectively investigated the role of (neo)adjuvant chemotherapy in patients with primary, localized angiosarcoma. Methods: We selected all patients with primary, localized angiosarcoma, who had received radical surgery between January 2005 and December 2019 at 33 European sarcoma reference centers. The primary objective was to compare the outcome of patients who received (neo)adjuvant chemotherapy versus those who did not, in terms of overall survival (OS), disease-free survival (DFS) and distant metastasis-free survival (DMFS). To reduce the risk of confounding due to imbalance, a propensity-score matching(PSM) was performed. Finally, subgroups analysis was performed according to tumor site, tumor size (< 50 mm or ≥ 50 mm) and patients predicted 10-years OS according to the nomogram sarculator (two different cutoff-values were applied: ≤ 33% or > 33% and < 60% or ≥ 60%). Results: 362 patients were analyzed: 149 (41.2%; treated group) received (neo) adjuvant chemotherapy and 213 (58.6%; control group) did not. The median follow-up for the OS endpoint was 5.1 years (95% CI: 4.0–5.5). The OS-HR was 0.58 (95%CI: 0.40–0.83; p-value = 0.003) in the univariate analysis and 0.74 (95% CI: 0.38–1.43; p = 0.367) in the PSM analysis. The DFS-HR was 0.75 (95% CI: 0.57–0.98; p-value = 0.036) in the univariate analysis, and 0.91 (95% CI:0.56–1.48; p-value = 0.7) in the PSM analysis. The DMFS-HR was 0.75 (95% CI: 0.55–1.02; p-value = 0.065) in univariate analysis and 0.92 (95% CI: 0.53–1.61; p-value = 0.769) in the PSM analysis. Subgroup analysis revealed no heterogeneity of results in strata of tumor site. On the contrary, there was a trend for heterogeneity according to tumor size and patient's risk of death. For all the endpoints analyzed, patients with tumors smaller than 50 mm or at lower risk of death seem to have no benefit from chemotherapy, while patients with larger tumors or at higher risk of death at 10 years seem to derive substantial benef

Published
2022

9. Corrigendum to “SELNET clinical practice guidelines for soft tissue sarcoma and GIST” [Cancer Treat. Rev. 102 (2021) 102312]

Author

Blay, J.Y., Hindi, N., Bollard, J., Aguiar, S., Jr., Angel, M., Araya, B., Badilla, R., Bernabeu, D., Campos, F., Caro-Sánchez, C.H.S., Carvajal, B., Carvajal Montoya, A., Casavilca-Zambrano, S., Castro-Oliden, V., Chacón, M., Clara, M., Collini, P., Correa Genoroso, R., Costa, F.D., Cuellar, M., dei Tos, A.P., Dominguez Malagon, H.R., Donati, D., Dufresne, A., Eriksson, M., Farias-Loza, M., Fernandez, P., Frezza, A.M., Frisoni, T., Garcia-Ortega, D.Y., Gelderblom, H., Gouin, F., Gómez-Mateo, M.C., Gronchi, A., Haro, J., Huanca, L., Jimenez, N., Karanian, M., Kasper, B., Lopes David, B.B., Lopez-Pousa, A., Lutter, G., Martinez-Said, H., Martinez-Tlahuel, J., Mello, C.A., Morales Pérez, J.M., Moura David, S., Nascimento, A.G., Ortiz-Cruz, E.J., Palmerini, E., Patel, S., Pfluger, Y., Provenzano, S., Righi, A., Rodriguez, A., Salas, R., Santos, T.T.G., Scotlandi, K., Soule, T., Stacchiotti, S., Valverde, C., Waisberg, F., Zamora Estrada, E., and Martin-Broto, J.

Published
2023
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11. Prognostic time dependence of deletions affecting codons 557 and/or 558 of KIT gene for relapse-free survival (RFS) in localized GIST: a Spanish Group for Sarcoma Research (GEIS) Study

Author

Martin-Broto, J., Gutierrez, A., Garcia-del-Muro, X., Lopez-Guerrero, J.A., Martinez-Trufero, J., de Sande, L.M., Lainez, N., Maurel, J., De Juan, A., Losa, F., Andres, R., Casado, A., Tejido, P.G., Blanco, R., Carles, J., Bellmunt, J., Gomez-España, A., Ramos, R., Martinez-Serra, J., Llombart-Bosch, A., and Poveda, A.

Published
2010
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12. 1932P First in human trial of CEB-01 for retroperitoneal soft tissue sarcoma

Author

González, J.A., Sebio, A., Beveridge, R. Díaz, Castellanos, J.F. Orbis, Andújar, R. López, Álvarez, R. Álvarez, Asencio, J. Manuel, Martin-Broto, J., Hindi, N., Jimenez, M., Villarejo-Campos, P., García, C. Serrano, Rodríguez, N., Boix, S. Castro, Campos, A. Perez, Casas, F. Cano, García, J.A. Tornero, Marti, L., Krauel, L., and Pousa, A. Lopez

Published
2023
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13. 1926P Trabectedin plus radiotherapy on symptomatic advanced sarcoma patients: Results from the SYNERGIAS study - A Spanish group for research in sarcoma (GEIS) phase II study

Author

Martin-Broto, J., Kopeckova, K., Azinovic, I., Jurado, J. Cruz, Guzmán, L., Alvarez, R.M., Herraez, A. Casado, Morales, C.M. Valverde, Sanchez, A. Redondo, Lleida, R. Teres, Gonzalez, A. Alvarez, Dolado, M.C., Doval, A., Belinchón, B., Merino, J.A., Mendez, R., Ledesma, P., Gutierrez, A., Da Silva Moura, D., and Hindi Muñiz, N.

Published
2023
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17. 1536P Biological processes associated with the efficacy of sunitinib plus nivolumab in soft-tissue sarcoma: Correlative studies of the IMMUNOSARC trial of Spanish (GEIS) and Italian (ISG) sarcoma groups

Author

Lacerenza, S., Moura, D., Peña-Chilet, M., Hindi, N., Dopazo, J., Sanchez-Bustos, P., Grignani, G., Martinez-Trufero, J., Redondo, A., Valverde, C., Stacchiotti, S., Lopez Pousa, A., D’Ambrosio, L., Perez-Vega, H., Collini, P., Lopez-Martin, J.A., and Martin Broto, J.

Published
2021
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18. 1520O REGISTRI: Regorafenib in first-line of KIT/PDGFR wild type advanced GIST: Capatalize the A Spanish (GEIS), Italian (ISG) and French Sarcoma Group (FSG) phase II trial

Author

Martin Broto, J., Valverde, C., Hindi, N., Vincenzi, B., Martinez-Trufero, J., Grignani, G., Italiano, A., Lavernia, J., Gonzalez-Campora, R., Vallejo, A., Hernandez-Jover, D., Gutierrez, A., Serrano, C., Moura, D., Lopez-Guerrero, J.A., Cruz, J., Fernández-Serra, A., Blay, J-Y., Fumagalli, E.R., and Martinez Marin, V.

Published
2021
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22. 1669O - IMMUNOSARC: A collaborative Spanish (GEIS) and Italian (ISG) sarcoma groups phase I/II trial of sunitinib plus nivolumab in advanced soft tissue and bone sarcomas: Results of the phase II- soft-tissue sarcoma cohort

Author

Broto, J Martin, Hindi, N., Grignani, G.E., Trufero, J Martinez, Redondo, A., Valverde, C., Pousa, A Lopez, Stacchiotti, S., Palmerini, E., de Alava, E., Moura, D.S., Vega, H Perez, Collini, P., Otero, I., Ledesma, P., Marchesi, E., D’Ambrosio, L., and Martin, J A Lopez

Published
2019
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25. LBA55 - Time to definitive failure to the first tyrosine kinase inhibitor in localized gastrointestinal stromal tumors (GIST) treated with imatinib as an adjuvant: Final results of the EORTC STBSG, AGITG, UNICANCER, FSG, ISG, and GEIS randomized trial

Author

Casali, P.G., Le Cesne, A., Poveda, A., Kotasek, D., Rutkowski, P., Hohenberger, P., Fumagalli, E., Judson, I., Italiano, A., Gelderblom, H., Penel, N., Kopp, H-G., Goldstein, D., Broto, J. Martin, Gronchi, A., Wardelmann, E., Marreaud, S., Zalcberg, J., Litière, S., and Blay, J-Y.

Published
2017
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26. 1512P - Clinicopathologic features and long-term follow-up of metastatic gastrointestinal stromal tumor (GIST) patients (pts) with durable response (≥ 5 years) to frontline imatinib (IM): A case-control study from GEIS

Author

Serrano, C., Lopez Pousa, A., Pajares, I., Valverde Morales, C., Duran, J., Rubió-Casadevall, J., Safont, M.J., Martinez, V., Díaz Beveridge, R., Estival, A., Vicente Baz, D., Sebio Garcia, A., Hindi, N., Landolfi, S., Olivares, D., Garcia-Valverde, A., Ledesma, P., Arribas, J., Carles Galceran, J., and Martin Broto, J.

Published
2017
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27. 1505P - Analysis of expression of immunomodulation factors in alveolar soft-part sarcoma: a retrospective study from the Spanish Group for Research on Sarcoma (GEIS)

Author

Hindi, N., Fernandez-Serra, A., Martinez-Trufero, J., Carranza-Carranza, A., Lopez-Pousa, A., Lavernia, J., Arranz, J.L., López Alegret, R., Martinez-Garcia, J., Valverde Morales, C., Cano, J.M., Vaz, M.A., Moura, D.S., Bagué, S., Gonzalez-Campora, R., Lopez-Guerrero, J.A., and Martin-Broto, J.

Published
2017
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29. LBA6_PR - sarcoma Full-dose neoadjuvant anthracycline + ifosfamide chemotherapy is associated with a relapse free survival (RFS) and overall survival (OS) benefit in localized high-risk adult soft tissue sarcomas (STS) of the extremities and trunk wall: Interim analysis of a prospective randomized trial

Author

Gronchi, A., Ferrari, S., Quagliuolo, V., Broto, J. Martin, Lopez-Pousa, A., Grignani, G., Ferraresi, V., Blay, J.-Y., Rutkowski, P., Merlo, F.D., Marchesi, E., Ledesma, P., De Tos, A.P.i., Rosell, S. Bague, Coindre, J.-M., Morosi, C., Stacchiotti, S., Picci, P., Bruzzi, P., and Casali, P.G.

Published
2016
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31. LBA46 - Phase 2 Trial to Evaluate the Efficacy and Safety of Dovitinib in Patients (Pts) with Gastrointestinal Stromal Tumor (Gist) Refractory and/or Intolerant to Imatinib (Im)

Author

Joensuu, H., Blay, J-Y., Comandone, A., Martin Broto, J., Fumagalli, E., Grignani, G.E., Garcia Del Muro, X., Adenis, A., Valverde Morales, C., Lopez Pousa, A., Bouché, O., Bui, B., Bauer, S., Barone, C., Weiss, C., Crippa, S., Camozzi, M., Castellana, R., and Le Cesne, A.

Published
2014
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32. 1453P - Solitary Fibrous Tumor (Sft): a Registry Program to Assess Frequency and Managemente in Our Country. a Spanish Group for Research on Sarcoma (Geis) Study

Author

Cruz Jurado, J., Valverde Morales, C., Vaz, M.A., Alvarez Alvarez, R., Lopez-Pousa, A., Sancho Marquez, P., Carrasco, J.A., Martinez-Trufero, J., Sala Gonzalez, M.A., Arranz, J.L., De Sande González, L.M., Blanco Sanchez, M.J., Orbegoso, C., Pérez-Fidalgo, J.A., Martinez García, J., Lavernia, J., Sevilla, I., Cano, J.M., Meana, A., and Martin Broto, J.

Published
2014
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34. 1452P - Multidisciplinary Treatment Outcome of Desmoid-Type Fibromatosis (Dtf). a Registry-Based Study from Spanish Group for Research on Sarcoma (Geis)

Author

Martinez-Trufero, J., Alvarez Alvarez, R., Lopez Pousa, A., Sevilla, I., Sancho Marquez, P., Orbegoso, C., Cruz Jurado, J., Sala Gonzalez, M.A., Valverde Morales, C., Blanco Sanchez, M.J., Pérez-Fidalgo, J.A., Berros, J.P., Martinez García, J., Arranz, J.L., Meana, A., López-Martín, J.A., Rubió, J., Cano, J.M., Juez-Martel, I., and Martin Broto, J.

Published
2014
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35. 227P - Prognosis of Phosphorylated-Insulin Growth Factor Receptor (P-Igf-1R) and Metalloproteinase-3 (Mmp3) Expression in Advanced Gastrointestinal Stromal Tumors (Gist) Patients Treated with Imatinib. a Geis Study

Author

Maurel, J., Lopez-Pousa, A., Calabuig, S., Bagué, S., Del Muro, X. García, Sanjuan, X., Rubió, J., Cuatrecasas, M., Martinez-Trufero, J., Horndler, C., Fra, J., Morales, C. Valverde, Redondo, A., Poveda, A.M., Sevilla, I., Lainez, N., Rubini, M., Albéniz, X. García, Broto, J. Martin, and De Álava, E.

Published
2014
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