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Your search keyword '"Alini, Mauro"' showing total 39 results
Start Over Author "Alini, Mauro" Publisher elsevier ltd
39 results on '"Alini, Mauro"'

37. Contributors

Author

Abraham, Gustavo A., Ahlfeld, Tilman, Alini, Mauro, Allen, Josephine B., Ambrosio, Luigi, Arango-Ospina, Marcela, Armiento, Angela R., Baleizão, Carlos, Beckmann, Matthias W., Beier, Justus P., Best, Serena M., Bleisinger, Nathalie, Boccaccini, Aldo R., Cai, Aijia, Caracciolo, Pablo C., D’Amora, Ugo, Dittrich, Ralf, Epple, Matthias, Farinha, José Paulo S., Fehnel, Alexandra, Gelinsky, Michael, Hahn, Artur, Huang, Jie, James, Bryan D., Kannan, Rahasudha, Kingham, Paul J., Kuna, Vijay Kumar, Kurz, Felix T., Kuth, Sonja, Lee, Sangwon, Liu, Jessica Z., Liverani, Liliana, Lu, Helen H., Ludtka, Christopher M., Ma, Peter X., Mano, João F., Mansbridge, Jonathan, Morgante, Debora, Mouriño, Viviana, Nazhat, Showan N., Oliveira, J. Miguel, Park, Hyeree, Parmentier, Laurens, Pina, Sandra, Popov Pereira da Cunha, Matthäus D., Raucci, Maria G., Reis, Rui L., Rivero, Guadalupe, Ronca, Alfredo, Rosenzweig, Derek H., Ruhl, Tim, Ruther, Florian, Schäfer, Benedikt, Sokolova, Viktoriya, Southgate, Jennifer, Tavares, Márcia T., Ursino, Heather L., Vernengo, Andrea J., Van Vlierberghe, Sandra, Vogt, Lena, and Wei, Guobao

Published
2022
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38. Sound-based assembly of three-dimensional cellularized and acellularized constructs.

Author

Tognato R, Parolini R, Jahangir S, Ma J, Florczak S, Richards RG, Levato R, Alini M, and Serra T

Abstract

Herein we show an accessible technique based on Faraday waves that assist the rapid assembly of osteoinductive β-Tricalcium phosphate (β-TCP) particles as well as human osteoblast pre-assembled in spheroids. The hydrodynamic forces originating at 'seabed' of the assembly chamber can be used to tightly aggregate inorganic and biological entities at packing densities that resemble those of native tissues. Additionally, following a layer-by-layer assembly procedure, centimeter scaled osteoinductive three-dimensional and cellularized constructs have been fabricated. We showed that the intimate connection between biological building blocks is essential in engineering living system able of localized mineral deposition. Our results demonstrate, for the first time, the possibility to obtain three-dimensional cellularized and acellularized anisotropic constructs using Faraday waves., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)

Published
2023
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39. Sound-based assembly of a microcapillary network in a saturn-like tumor model for drug testing.

Author

Di Marzio N, Ananthanarayanan P, Guex AG, Alini M, Riganti C, and Serra T

Abstract

The tumor microenvironment (TME), consisting of extracellular matrix, proteins, stromal cells, and a vascular system, is reported to have a key role in cancer progression and prognosis. Thereby, the interaction between the vascular network and tumor mass is an important feature of the TME since the anticancer agents which are delivered to the TME can trigger the vascular response and influence the therapeutic outcome of the treatment. To identify and develop new therapeutic strategies, 3D in vitro models that recapitulate the complexity of the TME are urgently needed. Among them, vascularized tumor models are a promising approach, allowing to target tumor angiogenesis and reduce tumor growth. By using sound patterning, cells can be condensed locally into highly reproducible patterns through the action of mild hydrodynamic forces. Here, we use a soundwave-driven cell assembly approach to create a ring-shaped microcapillary network in fibrin hydrogel. Then, we generate a 3D vascularized tumor model by combining a tumor heterotypic spheroid, consisting of fibroblasts and Malignant Pleural Mesothelioma (MPM) cells, with the surrounding vascular ring. Based on its shape, we name it Saturn-like vascularized Tumor Model (STM). The growth of the microcapillary network is monitored over time by fluorescence imaging. The area covered by the microcapillary network, and its continuous increase in presence of the heterotypic tumor spheroid was monitored. Interestingly, this effect is enhanced when treating the STM with the anticancer agent Cisplatin. Overall, we show the use of sound patterning as a fast and cell-friendly approach to spatially organize and condense cells, to generate a 3D in vitro platform from which simple readouts of drug tests can be extracted by image analysis, with the potential to provide a model system for tailored tumor therapy., Competing Interests: Tiziano Serra is co-founder of Mimix Biotherapeutics Ltd. (without financial support) which explores the technology in this manuscript. The company had no role in the study design, data interpretation or manuscript writing., (© 2022 The Authors.)

Published
2022
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