1. Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors
- Author
-
Jagat Narula, Sanghoon Shin, Matthew J. Budoff, Martin Hadamitzky, Jung Hyun Choi, Habib Samady, Daniel S. Berman, Filippo Cademartiri, Ki-Bum Won, Edoardo Conte, Fay Y. Lin, Pedro de Araújo Gonçalves, Sang Eun Lee, Jeroen J. Bax, Renu Virmani, Yong Jin Kim, Byoung Kwon Lee, Hyung Bok Park, Hyuk Jae Chang, Gianluca Pontone, Ji Min Sung, Daniele Andreini, Kavitha Chinnaiyan, Erica Maffei, Jonathon Leipsic, Ilan Gottlieb, Ran Heo, James K. Min, Leslee J. Shaw, Hugo Marques, and Eun Ju Chun
- Subjects
0301 basic medicine ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Interquartile range ,Internal medicine ,medicine ,Coronary computed tomography angiography ,Coronary atherosclerosis ,Computed tomography angiography ,Predictive marker ,Triglyceride ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,Atherogenic index of plasma ,medicine.disease ,Atherosclerosis ,030104 developmental biology ,Atheroma ,chemistry ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background and aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma athe-rogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA).Methods: A total of 1488 adults (60.9 +/- 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concen-trations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) >1.0%/year. All participants were divided into three groups based on AIP tertiles.Results: Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02-2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV.Conclusions: Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.
- Published
- 2021