38 results on '"van Cruchten A"'
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2. Biological variability hampers the use of skeletal staining methods in zebrafish embryo developmental toxicity assays
3. Ontogeny of renal, hepatic, and placental expression of ATP-binding cassette and solute carrier transporters in the rat and the rabbit
4. Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice
5. Antioxidants reduce reactive oxygen species but not embryotoxicity in the metabolic Danio rerio test (mDarT)
6. In vitro CYP1A activity in the zebrafish: temporal but low metabolite levels during organogenesis and lack of gender differences in the adult stage
7. Incubation at 32.5 °C and above causes malformations in the zebrafish embryo
8. Endocrine disruptors and female fertility: Focus on (bovine) ovarian follicular physiology
9. The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol
10. Detection of nonsterol isoprenoids by HPLC–MS/MS
11. Proliferation patterns in the canine endometrium during the estrous cycle
12. Apoptosis in the canine endometrium during the estrous cycle
13. In vitro biotransformation of proteratogens in different laboratory animal models, including the zebrafish
14. Exploring distinct zebrafish (Danio rerio) cytochrome P450 biotransformation activity for proteratogen investigation
15. Gene expression profiling of key nucleases in the juvenile Göttingen minipig
16. The ontogeny of hepatic CYP450 protein abundance in the developing Göttingen Minipig: a new step towards a juvenile PBPK model
17. Ontogeny of key zebrafish genes involved in the disposition of xenobiotics from the embryonic until the juvenile stage
18. Preterm piglets as a translational model for premature babies: focus on hepatic drug metabolism
19. From coincubation to preincubation: Strategy adjustments in the mDarT
20. Localization of cytochrome P450 activity in the zebrafish embryo and larva
21. UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
22. Co-incubation with liver microsomes in the mDarT, a bridge too far?
23. Localization of cytochrome P450 activity in the zebrafish embryo and larva
24. Preterm birth: Epidemiology, long-term morbidity and translational models
25. In vitro metabolism of mammalian proteratogens in the zebrafish: A preliminary investigation
26. In vitro characterization and ontogeny of CYP3A activity in the zebrafish
27. Embryotoxicity in the mDarT: Is oxidative stress the key driver?
28. Ontogeny of drug metabolism in the zebrafish: An in vitro study using human CYP-specific substrates
29. In vitro drug metabolism in juvenile non-rodent species: State-of-the-art
30. Ontogeny of CYP1A in the zebrafish: An in vitro investigation
31. Optimization of the co-incubation conditions in the mDarT assay
32. Is CYP3A activity in the liver of adult zebrafish influenced by tricaine methanesulfonate (MS-222)?
33. The zebrafish embryo: Fit for all purposes?
34. Lack of in vitro CYP3A activity in early zebrafish embryos
35. Ontogeny of CYP3A in the liver of the Göttingen minipig: An immunohistochemical and functional evaluation
36. In vitro CYP1A activity in the zebrafish: Effects of gender, temperature and developmental stage
37. Temperatures of 32.5 °C and above impact zebrafish embryonic development
38. Ontogeny of the drug efflux transporter P-glycoprotein in the small intestine of the pig: A preliminary investigation
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