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Start Over Author "Vildan Caner" Publisher elsevier inc.
2 results on '"Vildan Caner"'

1. Characterizing the Association Between Toll-like Receptor Subtypes and Nephrolithiasis With Renal Inflammation in an Animal Model

Author

Erkan Olcucuoglu, Nilay Şen Türk, Vildan Caner, Ömer Levent Tuncay, Mahmut Taha Ölçücü, Serdar Yalcin, and Kerem Teke

Subjects
0301 basic medicine, Male, ethylene glycol, Urine, animal cell, Wistar rat, Gastroenterology, oxalic acid, bladder stone, toll like receptor 11, toll like receptor 6, 0302 clinical medicine, toll like receptor 3, toll like receptor 1, nephritis, toll like receptor 2, calcium oxalate, Medicine, rat, animal, Receptor, Toll-like receptor, Kidney, hyperoxaluria, medicine.diagnostic_test, messenger RNA, Toll-Like Receptors, toll like receptor, medicine.anatomical_structure, priority journal, classification, real time polymerase chain reaction, 030220 oncology & carcinogenesis, histopathology, kidney injury, microscopy, medicine.symptom, medicine.medical_specialty, bilateral nephrectomy, Urology, stone formation, animal experiment, kidney biopsy, Inflammation, urine level, Article, animal tissue, in vivo study, 03 medical and health sciences, Kidney Calculi, In vivo, Internal medicine, Biopsy, Animals, controlled study, Rats, Wistar, protein expression, nonhuman, business.industry, animal model, disease model, disease association, toll like receptor 7, Disease Models, Animal, 030104 developmental biology, physiology, business, Bilateral Nephrectomy, nephrolithiasis, urine sampling
Abstract

Objective To show experimentally induced renal stone disease and to evaluate secondary inflammatory responses in vivo, and to characterize changes in the expression of Toll-like receptor (TLR) subtypes in this model. Methods Twenty 5- to 6-week-old male Wistar rats were divided into control and hyperoxaluria groups (n = 10 per group) and were supplied with normal water or 1% ethylene glycol, respectively, for 16 weeks. The animals were then placed in metabolic cages, and urine was collected for a 24-hour urine oxalate level evaluation. Following sacrifice, rats were subjected to bilateral nephrectomy and both kidneys were histopathologically evaluated. A 1-mm3 biopsy section from the right kidney of each rat was subjected to real-time polymerase chain reaction of the TLR expression. Results At the end of week 16, the hyperoxaluria group had a higher mean 24-hour urine oxalate level (1.91) than the control group (0.29) (P

Published
2018

2. Human TLR gene family members are differentially expressed in patients with urothelial carcinoma of the bladder

Author

Ikbal Cansu Baris, Levent Elmas, Aykut Başer, Seda Sabah-Ozcan, Taha Olcucu, Vildan Caner, Saadettin Eskicorapci, Levent Tuncay, and Nilay Şen Türk

Subjects
0301 basic medicine, bladder carcinoma, Male, interleukin 1beta, very elderly, Urine, toll like receptor 10, toll like receptor 5, toll like receptor 6, 0302 clinical medicine, toll like receptor 3, toll like receptor 4, toll like receptor 2, transitional cell carcinoma, Gene expression, middle aged, cytokine, bladder tumor, Medicine, Protein Isoforms, genetics, Receptor, Aged, 80 and over, clinical article, messenger RNA, adult, Toll-Like Receptors, toll like receptor, gene expression regulation, Acquired immune system, Gene Expression Regulation, Neoplastic, aged, RNA isolation, female, Oncology, priority journal, real time polymerase chain reaction, 030220 oncology & carcinogenesis, Multigene Family, isoprotein, Cytokines, Urothelial carcinoma, Inflammation Mediators, TLR10, autacoid, Urology, interleukin 6, interleukin 8, Article, Proinflammatory cytokine, TLR expression, 03 medical and health sciences, bladder injury, gene expression profiling, Gene family, Humans, human, Proinflammatory cytokines, Messenger RNA, Carcinoma, Transitional Cell, business.industry, cancer staging, toll like receptor 7, enzyme linked immunosorbent assay, 030104 developmental biology, Urinary Bladder Neoplasms, Tumor progression, tumor volume, Immunology, gene expression, business, neoplasm
Abstract

Purpose Toll-like receptors (TLRs) have an important role in the activation of both innate and adaptive immunity in response to pathogens and endogenous danger signals from damaged or dying cells. The aim of this study was to determine the relationship between urothelial carcinoma (UC) and TLR expression. Basic procedures Real-time polymerase chain reaction evaluation was made of the messenger RNA expression of TLRs 1–10 in 24 UC samples and 46 nontumoral bladder tissue samples. The levels of proinflammatory cytokines (IL-1β IL-6, and IL-8) in the urine samples were also determined with enzyme-linked immunosorbent assay. Main findings TLR2–7 and TLR10 expressions were significantly higher in UC than in the control group (P

Published
2017

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