44 results on '"Uchida, Naoya"'
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2. Ex vivo culture resting time impacts transplantation outcomes of genome-edited human hematopoietic stem and progenitor cells in xenograft mouse models
3. Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation
4. Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells
5. A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions
6. Disease severity impacts plerixafor-mobilized stem cell collection in patients with sickle cell disease
7. Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models
8. Intrabone transplantation of CD34+ cells with optimized delivery does not enhance engraftment in a rhesus macaque model
9. Myelodysplastic syndrome unrelated to lentiviral vector in a patient treated with gene therapy for sickle cell disease
10. Ex vivo immunological evaluation of stable mixed chimeric patients after matched related donor allogeneic transplantation in sickle cell disease
11. Genome editing of HBG1 and HBG2 to induce fetal hemoglobin
12. Fetal hemoglobin and F-cell variance in mobilized CD34+ cell-transplanted rhesus monkeys
13. Robust erythroid differentiation system for rhesus hematopoietic progenitor cells allowing preclinical screening of genetic treatment strategies for the hemoglobinopathies
14. Gene therapy for sickle cell disease: An update
15. High-level embryonic globin production with efficient erythroid differentiation from a K562 erythroleukemia cell line
16. Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study
17. TRIM5α Variations Influence Transduction Efficiency With Lentiviral Vectors in Both Human and Rhesus CD34+ Cells In Vitro and In Vivo
18. MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway
19. Peripheral blood stem cell transplants do not result in endometrial stromal engraftment
20. Optimization of Lentiviral ß-Globin Vectors in a Forward Orientation to Enhance Therapeutic Effectiveness for Sickle Cell Disease
21. CD117 Antibody-Drug Conjugate Conditioning Allows Efficient Engraftment of Gene-Modified CD34+ Cells with Fertility Preservation in a Rhesus Gene Therapy Model
22. 305 - CD117 Antibody Drug Conjugate-Based Conditioning Enables Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model
23. 291 - Optimization of Autologous Hematopoietic Progenitor Stem Cell Apheresis Collection from Plerixafor-Mobilized Patients with Sickle Cell Disease
24. 3154 – RHESUS MACAQUES AS NATURAL MODELS FOR AGE-RELATED CLONAL HEMATOPOIESIS
25. A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates
26. Durable and Robust Fetal Globin Induction without Anemia in Rhesus Monkeys Following Autologous Hematopoietic Stem Cell Transplant with BCL11A Erythroid Enhancer Editing
27. Development of a Clinically Applicable Method for High-Efficiency Gene Correction of Plerixafor-Mobilized CD34+ Cells from Patients with Sickle Cell Disease
28. Bone Marrow Characterization in Sickle Cell Disease: Inflammation and Stress Erythropoiesis Lead to Suboptimal CD34 Recovery Compared to Normal Volunteer Bone Marrow
29. More Efficient Generation of β-Globin-Expressing Erythroid Cells Using Stromal Cell-Derived Induced Pluripotent Stem Cells
30. β-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived Sacs
31. CD34+CXCR4(CD184)+ Cells Differentiate Into Myeloid Dendritic Cell Progenitors
32. Generation Of Mature Erythroid Cells From Human Embryonic Stem Cell Derived Sacs and Optimization Of Erythroid Cell Generation
33. Peripheral Blood As a Source Of Cells For Regenerative Medicine Applications In Sickle Cell Disease
34. Discordance Between Peripheral Blood and Tissue CD4+ Lymphocyte Reconstitution In Rhesus Monkeys Following Autologous Hematopoietic CD34+ Cell Transplantation: An In Vivo imaging Study
35. Determining Limitations in Human CD34+ Cell Transduction with An HIV1-Based Lentiviral Vector,
36. High Transgene Expression Rates After Extended Follow up Among Rhesus Macaque Recipients of Autologous Hematopoietic Stem Cells Transduced with a Modified HIV1-Based Lentiviral Vector
37. TRIM5α Variation Affects Lentiviral Transduction Efficiency for Long-Term Hematopoietic Repopulating Cells in a Rhesus Stem Cell Transplantation Model
38. Evaluation of Human and Rhesus CD34+CXCR4+ and CD34+CXCR4- Subpopulations
39. Chicken HS4 Insulators Have Minimal Functions in Human Hematopoietic Cells That Were Transduced with An HIV1-Based Lentiviral Vector.
40. A Practical Erythroid Assay in Humanized Xenograft Mouse Model
41. Development of An HIV1-Based Lentiviral Vector Able to Transduce Both Human and Rhesus Blood Cells.
42. Long-Term Vector Integration Site Analysis Following Retroviral Mediated Gene Transfer to Hematopoietic Stem Cells for the Treatment of HIV Infection.
43. Low Dose Busulfan Produces Efficient Human Cell Engraftment in Immunodeficient Mice.
44. MLL-AF4 and FLT3 Activation Synergize To Induce Multi Step Leukemogenesis.
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