67 results on '"Sobie, Eric"'
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2. A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals
3. A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines
4. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
5. Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking
6. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
7. Parameter Sensitivity Analysis of Stochastic Models Provides Insights into Cardiac Calcium Sparks
8. 30 - Computational Prediction of Drug-Induced Arrhythmias
9. Dynamics of Calcium Sparks and Calcium Leak in the Heart
10. Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis
11. Predicting Local SR Ca2+ Dynamics during Ca2+ Wave Propagation in Ventricular Myocytes
12. Models of cardiac excitation–contraction coupling in ventricular myocytes
13. Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression
14. β-Adrenergic Receptor Activation Induces Internalization of Cardiac Cav1.2 Channel Complexes through a β-Arrestin 1-mediated Pathway
15. Moment Closure for Local Control Models of Calcium-Induced Calcium Release in Cardiac Myocytes
16. A Probability Density Approach to Modeling Local Control of Calcium-Induced Calcium Release in Cardiac Myocytes
17. The Ryanodine Receptor Patchwork: Knitting Calcium Spark Dynamics
18. Modeling the spatiotemporal properties of crosstalk between RYR and IP3R-mediated Ca2+release in failing cardiomyocytes
19. Building Containerized Workflows Using the BioDepot-Workflow-Builder
20. Contributors
21. Termination of Cardiac Ca2+ Sparks: An Investigative Mathematical Model of Calcium-Induced Calcium Release
22. Using a Genetic Algorithm to Parameterize a Mathematical Model of a Porcine Ventricular Cardiomyocyte
23. Investigational Treatments for COVID-19 May Increase Ventricular Arrhythmia Risk through Drug Interactions
24. Machine Learning Techniques to Classify the Severity of Novel SCN5A Variants
25. Modeling the Crosstalk between Ryanodine and IP3 Receptors in Cardiac Myocytes
26. A Comparative Analysis of Parameter Estimation Strategies for Mathematical Modeling of Ion Channel Gating
27. Combining Systems Pharmacology Modeling with Machine Learning to Identify Sub-Populations at Risk of Arrhythmia
28. Development of an Integrated Human Model of Electrophysiology and Actin-Myosin Binding to Describe Sarcomere Force Generation in Cardiomyocytes
29. Mechanistic Differences between Ca2+Sparks and Ca2Puffs Revealed Through Simulations of Heterogeneous Populations
30. Population-Based Mathematical Modeling to Deduce Disease-Causing Cardiac Na+ Channel Gating Defects
31. Slow Delayed Rectifier K+ Current Stabilizes Ventricular Action Potentials across Species
32. Population-Based Mechanistic Modeling Allows for Quantitative Predictions of Drug Responses across Cell Types
33. An Integrated Model of Human Beta-Adrenergic Signaling and Ventricular Electrophysiology Reveals Contributors to Positive Inotropy
34. Human Mesenchymal Stem Cell Paracrine Signaling Counteracts Heterocellular Coupling Effects on Cardiac Contractility and Arrhythomgenicity
35. Physiologic gating properties of unitary cardiac L-type Ca2+ channels
36. Quantitative Predictions of Adult Human Drug Effects from Stem Cell-Derived Myocyte Physiology
37. Population-Based Mathematical Modeling Facilitates the Interpretation of Dynamic Clamp Experiments in Cardiomyocytes
38. Integrated Analysis for Quantitative Predictions of Drug Induced Cardiotoxicity
39. Modeling Electrophysiological Interactions between Mesenchymal Stem Cells and Cardiomyocytes for Improved Cell Delivery Cardiotherapeutics
40. Simulations of Subcellular Heterogeneity in Calcium Blink Kinetics
41. Allosteric Activation of Na+-Ca2+ Exchange by L-Type Ca2+ Current Augments the Trigger Flux for SR Ca2+ Release in Ventricular Myocytes
42. Comprehensive Analysis of Behavioral Variability in Real and Simulated Populations of Rabbit Left Ventricular Cardiomyocytes
43. A Novel Classification Method with Superior Prediction of Drug Arrhythmia Risk
44. A Mechanistic Analysis of Variability Between Ventricular Cardiomyocytes
45. Overcoming Reverse Rate Dependence in Ventricular Cell Models
46. Activity of Both PKA and Camkii is Required for Maximal RyR Sensitivity Under Beta-Adrenergic Stimulation
47. Analysis of Spark Versus Non-Spark Mediated SR Calcium Leak using a Langevin Description of Stochastic Calcium Release
48. Factors Influencing Ca2+ Spark Refractoriness in Mouse
49. Quantitative Contributions to Electrical Propagation in 1D Cable Model
50. Parametric Sensitivity Analysis of the Most Recent Computational Models of Rabbit Cardiac Pacemaking
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