48 results on '"Nixon, Ralph A."'
Search Results
2. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF
3. Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model
4. Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments
5. The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models
6. In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model
7. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases
8. Aβ localization in abnormal endosomes: association with earliest Aβ elevations in AD and Down syndrome
9. Binding of cystatin C to Alzheimer’s amyloid β inhibits in vitro amyloid fibril formation
10. Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice
11. Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL
12. EFFECTS OF P38α MAP KINASE INHIBITION ON THE NEURODEGENERATIVE PHENOTYPE OF THE TS2 DOWN SYNDROME MOUSE MODEL
13. ANTAGONISM OF P38 MAPK ALPHA (P38α) REVERSES APP-INDUCED ENDOSOMAL ABNORMALITIES AND IMPROVES LYSOSOMAL FUNCTION IN DOWN SYNDROME FIBROBLASTS
14. Immunization targeting a minor plaque constituent clears Aβ and rescues behavioral deficits in an Alzheimer's disease mouse model
15. Presenilin 1 (PS1) is required for lysosome acidification: FAD mutations of PS1 cause loss of protein turnover by autophagy
16. Dynamic modeling of autophagy defects and their pathologic consequences in Alzheimer's disease and related diseases: Contribution of proteolysis impairment and axonal transport
17. P3-410: Alzheimer's disease–related endosome dysfunction induced by APP overexpression in neurons requires Rab5 overactivation
18. P1-079: Calpain inhibition by calpastatin overexpression reduces β-amyloid deposition in an APP transgenic mouse
19. P1-059: Cystatin B deletion in a mouse model of Alzheimer's disease, TgCRND8, ameliorates both autophagic-lysosomal and amyloid pathologies
20. P1-011: Dysregulation of amyloid precursor protein levels, but not Aβ levels in Ts65Dn mouse brain
21. P4-098: In vivo turnover of retrogradely transported proteins by autophagy is impaired in PS/APP transgenic mice
22. P4-080: Cystatin C protects neuronal cells against amyloid-β induced cytotoxicity
23. P2-061: APP expression modulates AD-related endosomal trafficking abnormalities in Down syndrome fibroblasts
24. P2-028: Functional analyses of AD-related endocytic trafficking defects in Down syndrome fibroblasts
25. P2-014: Dysregulation of brain APP in the Ts65Dn Down syndrome mouse
26. P1-107: In vivo MRI correlates of specific cholinergic circuitry loss in murine models of Down syndrome
27. O3-03-07: Presenilin-1 is required for macroautophagy: PS1 mutations causing AD confer loss of macroautophagy function
28. S4-03-01: Evidence that aberrant post-TGN trafficking of Alzheimer’s APP is sufficient to elevate brain A-beta 42 and may underlie mutant presenilin action
29. P2-069 Quantitative in vivo MR brain imaging in TS65DN mice: a murine model of down's syndrome
30. P2-061 Binding of cystatin C to amyloid beta inhibits amyloid fibril formation
31. P2-007 Age-associated behavioral, metabolic, and structural changes in wild-type littermates of Alzheimer's transgenic mice
32. P3-292 AD-related cathepsin D overexpression promotes mitochondrial-dependent apoptosis
33. P3-289 Neurodegeneration in a mouse model of Alzheimer's disease (AD): roles of apoptosis and autophagy
34. P1-272 Calpain mediates calcium-induced activation of the ERK 1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
35. P1-163 Autophagic vacuoles contain high beta and gamma secretase activities
36. S5-02-03 Endosomal pathology in early stage Alzheimer's disease
37. S4-03-04 Autophagy in Alzheimer's disease pathogenesis
38. Upregulation of the lysosomal system in experimental models of neuronal injury: Implications for Alzheimer's disease
39. Accelerated Aβ generation in AD models of lysosomal system upregulation
40. Stereologic analysis of vulnerable neocortical neurons in normal aging and Alzheimer's disease
41. Endosomal-lysosomal mechanisms in amyloido-genesis and neurodegeneration: Animal models
42. Endocytic alterations in human preclinical AD and a trisomic mouse model of down syndrome: Implications for β-amyloidogenesis
43. A versatile transition metal salt reaction for a wide range of common biochemical reagents: An instantaneous and quantifiable color test
44. Neuronal degenerative mechanisms as clues to pathogenesis and treatment of Alzheimer's disease
45. Volatile amines in mouse brain: A radioassay with picogram sensitivity
46. Comparison of cerebral sphingolipid metabolism in vivo in “quaking” and normal mice
47. Free radicals, proteolysis, and the degeneration of neurons in alzheimer disease: How essential is the β-amyloid link?
48. Neurotoxicity of a non-metabolizable amino acid, 1-aminocyclopentane-1-carboxylic acid (ACPC): ACPC transport mechanisms in tissues
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