1. Osteoclasts Pump Iron
- Author
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G. David Roodman
- Subjects
musculoskeletal diseases ,Physiology ,Cellular differentiation ,Iron ,Osteoclasts ,Iron/Transferrin ,Mice ,Osteoclast ,Receptors, Transferrin ,medicine ,Animals ,Bone Resorption ,Receptor ,Molecular Biology ,Transcription factor ,Calcium metabolism ,Organelle Biogenesis ,Chemistry ,Transferrin ,Cell Differentiation ,Cell Biology ,CREB-Binding Protein ,Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ,Cell biology ,Mitochondria ,medicine.anatomical_structure ,Biochemistry ,Mitochondrial biogenesis ,Gene Knockdown Techniques ,Trans-Activators ,Organelle biogenesis ,Reactive Oxygen Species ,Transcription Factors - Abstract
SummaryOsteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in generating a positive osteoclastogenic feedback loop.
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