1. Membrane Lipids Tune Synaptic Transmission by Direct Modulation of Presynaptic Potassium Channels
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Christophe Mulle, Mario Carta, Joana Lourenço, Silvia Viana DaSilva, Nelson Rebola, Zsolt Szabo, Christophe Blanchet, Carsten Schultz, André Nadler, Agathe Verraes, Frederic Lanore, Indisciplinary Institute for Neuroscience, UMR 5297, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), INSERM ERL U950, Membrane Traffic in Neuronal and Epithelial Morphogenesis, Institut National de la Santé et de la Recherche Médicale (INSERM), European Molecular Biology Laboratory [Heidelberg] (EMBL), and EIF Fellowship (project name KARTRAF), SYNSCAFF, the Conseil Regional of Aquitaine, the Fondation pour le Recherche Medicale, VANR ASD/LD, Dalhousie University, ESF EuroMembrane program (TraPPs)
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MESH: Hippocampus ,Potassium Channels ,Long-Term Potentiation ,MESH: Neurons ,Gating ,Hippocampus ,Synaptic Transmission ,MESH: Synapses ,Mice ,0302 clinical medicine ,Postsynaptic potential ,MESH: Animals ,Neurons ,0303 health sciences ,Chemistry ,General Neuroscience ,Pyramidal Cells ,MESH: Electric Stimulation ,Long-term potentiation ,MESH: Potassium Channels ,Potassium channel ,medicine.anatomical_structure ,Modulation ,Mossy Fibers, Hippocampal ,Excitatory postsynaptic potential ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Membrane lipids ,Neuroscience(all) ,Neurotransmission ,Biology ,03 medical and health sciences ,Membrane Lipids ,MESH: Long-Term Potentiation ,MESH: Mice, Inbred C57BL ,medicine ,MESH: Synaptic Transmission ,Animals ,MESH: Excitatory Postsynaptic Potentials ,MESH: Mice ,030304 developmental biology ,Post-tetanic potentiation ,MESH: Mossy Fibers, Hippocampal ,Excitatory Postsynaptic Potentials ,MESH: Pyramidal Cells ,Electric Stimulation ,Mice, Inbred C57BL ,Synaptic plasticity ,Synapses ,Biophysics ,Retrograde signaling ,Neuron ,MESH: Membrane Lipids ,Neuroscience ,030217 neurology & neurosurgery - Abstract
International audience; Voltage-gated potassium (Kv) channels are involved in action potential (AP) repolarization in excitable cells. Exogenous application of membrane-derived lipids, such as arachidonic acid (AA), regulates the gating of Kv channels. Whether membrane-derived lipids released under physiological conditions have an impact on neuronal coding through this mechanism is unknown. We show that AA released in an activity-dependent manner from postsynaptic hippocampal CA3 pyramidal cells acts as retrograde messenger, inducing a robust facilitation of mossy fiber (Mf) synaptic transmission over several minutes. AA acts by broadening presynaptic APs through the direct modulation of Kv channels. This form of short-term plasticity can be triggered when postsynaptic cell fires with physiologically relevant patterns and sets the threshold for the induction of the presynaptic form of long-term potentiation (LTP) at hippocampal Mf synapses. Hence, direct modulation of presynaptic Kv channels by activity-dependent release of lipids serves as a physiological mechanism for tuning synaptic transmission.
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